Symbolic representation of lenticule fusion with the cornea, symbolizing restored vision after LASIK surgery.

LASIK Complications? A New Hope for Ectasia Treatment

"Allogenic lenticule addition combined with corneal cross-linking shows promising results in treating post-LASIK ectasia with corneal thinning."


Post-LASIK ectasia, a potential complication following LASIK surgery, leads to progressive corneal thinning and bulging, resembling keratoconus. This condition can significantly impair vision, initially managed with glasses or contact lenses. However, as ectasia advances, surgical intervention becomes necessary when these options are no longer sufficient.

Corneal cross-linking (CXL) has emerged as a well-established method for halting the progression of keratoconus. Recent advancements in laser technology have led to the development of small incision lenticule extraction (SMILE), offering new possibilities for treating various corneal conditions. One such approach involves using stromal lenticules extracted during SMILE procedures to address hyperopia, corneal perforations, keratoconus, and even post-LASIK ectasia.

A recent case study investigates the long-term outcomes of combining lenticule addition with corneal cross-linking for treating post-LASIK ectasia accompanied by corneal thinning, providing valuable insights into this innovative technique.

The Innovative Technique: Lenticule Addition and Corneal Cross-Linking

Symbolic representation of lenticule fusion with the cornea, symbolizing restored vision after LASIK surgery.

The case report details the experience of a 26-year-old male who developed bilateral post-LASIK keratectasia two years after undergoing LASIK in 2009. By April 2015, the patient sought treatment for his left eye at the clinic, as he could not tolerate rigid gas permeable contact lenses. The patient's left eye underwent lenticule addition followed by corneal cross-linking.

A lenticule, with a central thickness of 77 µm and a peripheral thickness of 10 µm, was extracted from a myopic SMILE procedure. Using a Sinskey hook to open the original LASIK flap, a blunt spatula was then employed to lift the flap, and the fresh lenticule was inserted into the stroma, carefully centering it onto the apex of the cornea. Once properly positioned, the flap was repositioned, and a bandage contact lens was applied to the eye.

  • Medication Regimen: Post-operative care included levofloxacin four times daily for 3 days, fluorometholone 0.1% eight times daily, gradually reduced over 24 days, and tear supplements four times daily for one month.
  • CXL Procedure: Four months after lenticule addition, when corneal thickness was adequate (412 µm), CXL was performed using ParaCel and VibeX Xtra solutions, followed by ultraviolet treatment using the KXL System.
  • Post-CXL Care: This included antibiotic drops for one week and fluorometholone 0.1% for 16 days, tapered gradually, plus tear supplements four times daily for one month.
Remarkably, the patient’s uncorrected distance visual acuity (UDVA) stabilized at 20/125, while the best spectacle-corrected distance visual acuity (CDVA) was 20/40 with a stable refraction of -5.00 / -6.00 @ 100 degrees. Slit-lamp examination revealed no visual abnormalities, corneal haze, or rejection throughout the 30-month follow-up. Corneal thickness increased by 73 µm at the pupil center, and OCT images confirmed the lenticule's seamless integration with the surrounding corneal stroma.

A Promising Path Forward

This case presents a compelling treatment avenue for individuals grappling with keratectasia and keratoconus, especially those with thin corneal thicknesses (below 400 µm). By potentially delaying or averting the necessity for keratoplasty, this approach circumvents the associated complications and donor cornea limitations.

Lenticule addition combined with CXL demonstrates efficacy, safety, and stability, marking it as a promising surgical technique for post-LASIK ectasia. While this case involved a lenticule from a myopic patient, future studies incorporating hyperopic lenticules could further validate the long-term advantages of this surgical strategy for post-LASIK ectasia with thin corneas.

Ultimately, employing lenticule addition before CXL in post-LASIK ectasia patients experiencing progressive corneal thinning and bulging emerges as an effective strategy, carrying reduced risk and a shorter treatment duration compared to traditional lamellar keratoplasty, heralding a new era of hope for those seeking vision correction after LASIK complications.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1186/s12886-018-0967-z, Alternate LINK

Title: Thirty-Month Results After The Treatment Of Post-Lasik Ectasia With Allogenic Lenticule Addition And Corneal Cross-Linking: A Case Report

Subject: Ophthalmology

Journal: BMC Ophthalmology

Publisher: Springer Science and Business Media LLC

Authors: Meiyan Li, Dong Yang, Feng Zhao, Tian Han, Meng Li, Xingtao Zhou, Katherine Ni

Published: 2018-11-12

Everything You Need To Know

1

What is post-LASIK ectasia and how does it affect vision?

Post-LASIK ectasia is a condition that can occur after LASIK surgery, leading to progressive corneal thinning and bulging. This can result in vision impairment, often requiring management with glasses or contact lenses initially. However, if the condition advances, surgical intervention might become necessary.

2

Can you describe the innovative technique that combines lenticule addition and corneal cross-linking (CXL)?

The new technique involves two main components: lenticule addition and corneal cross-linking (CXL). Lenticule addition involves inserting a lenticule, which is a piece of corneal tissue, into the cornea to increase its thickness. Corneal cross-linking (CXL) is then performed to strengthen the cornea and halt the progression of ectasia. In the case study, the CXL was performed using ParaCel and VibeX Xtra solutions, followed by ultraviolet treatment using the KXL System.

3

How is the lenticule addition procedure performed, and what medications are used post-operatively?

During lenticule addition, a lenticule extracted from a SMILE procedure is inserted into the corneal stroma. A Sinskey hook is used to open the original LASIK flap, then a blunt spatula lifts the flap for lenticule placement. The lenticule, carefully positioned, thickens the cornea. Post-operatively, medication like levofloxacin and fluorometholone is administered to aid healing. Four months later, after sufficient corneal thickening, corneal cross-linking (CXL) is performed to stabilize the cornea.

4

What is the role of corneal cross-linking (CXL) in this treatment, and why is it important?

Corneal cross-linking (CXL) is significant because it strengthens the cornea by creating cross-links between collagen fibers, which helps to halt the progression of conditions like keratoconus and post-LASIK ectasia. CXL using ParaCel and VibeX Xtra solutions, followed by ultraviolet treatment using the KXL System, aims to improve the cornea's structural integrity. While the text describes medication and solutions, it does not describe the chemical process involved.

5

What are the potential benefits of using lenticule addition and corneal cross-linking (CXL) compared to more invasive surgical options?

This combined approach offers a less invasive alternative to keratoplasty (corneal transplant) for individuals with keratectasia and keratoconus, especially those with thin corneas. By increasing corneal thickness and halting the progression of ectasia, lenticule addition combined with corneal cross-linking (CXL) can potentially delay or eliminate the need for more invasive surgical procedures and their associated complications.

Newsletter Subscribe

Subscribe to get the latest articles and insights directly in your inbox.