Surreal illustration of a foot bathed in golden light, symbolizing healing of diabetic foot ulcers.

Healing Hope: Can Hypericum and Azadirachta Revolutionize Diabetic Foot Ulcer Treatment?

Mira Elwood in Health & Wellness November 2025 • 4 min read.

"Discover how a natural mixture of Hypericum perforatum and Azadirachta indica could offer new hope in managing and healing diabetic foot ulcers, potentially reducing the need for surgery."

Diabetic foot ulcers (DFUs) are a major global health concern, representing one of the most severe consequences of poorly controlled diabetes. With the number of affected individuals projected to rise dramatically, especially in developing nations, finding effective and accessible treatments is crucial. Current estimates suggest that diabetes affected 171 million people worldwide in 2000, and this figure is expected to double by 2030, reaching 366 million cases, according to the World Health Organization (WHO).

Advanced diabetes complications, including DFUs, pose a significant challenge, particularly in low-income countries, severely impacting patients, families, and healthcare systems. The potential risks associated with uncontrolled diabetes are well-documented; only a small percentage of patients meet the American Diabetes Association (ADA) recommended targets for blood pressure, LDL cholesterol, and HbA1c, especially in poorer countries.

Recognizing the urgent need for improved treatments, a recent study explored the use of a mixture of Hypericum perforatum (commonly known as St. John's Wort) and Azadirachta indica (Neem) in managing DFUs. Inspired by initial success with a patient suffering from extremely advanced foot ulcers, researchers investigated this treatment on a series of patients with less severe ulcers. This article summarizes the promising results observed in this case series, offering hope for a more effective and accessible approach to DFU management.

A Natural Approach to Healing Diabetic Foot Ulcers

Surreal illustration of a foot bathed in golden light, symbolizing healing of diabetic foot ulcers.

The study focused on patients attending Wound Care Units (WCU) in Italy between June 2012 and June 2013. All participants followed a standardized diagnostic and therapeutic scheme to manage their diabetes and any coexisting conditions. A key component of the treatment involved using a mixture of Hypericum perforatum and Azadirachta indica (marketed as Hyperoil™) for at-home care, contingent on well-compensated diabetes management at the WCU. Changes in HbA1c levels, pressure, and pain were carefully evaluated using paired t-tests to determine the treatment's effectiveness.

The results were promising. All 16 patients in the study experienced recovery from their DFUs within 2 to 10 months of starting the Hyperoil™ treatment. During this period, significant improvements were noted:

Improved HbA1c levels, indicating better glycemic control.
Elimination of pain associated with DFUs.
Better compensation for hypertension.

These findings suggest that Hyperoil™, combined with strict diabetes control, may offer a cost-effective and efficient option for managing advanced diabetic foot ulcers at home. This approach could significantly reduce the need for frequent hospital visits and specialized care, making treatment more accessible and improving patients' quality of life.

A Promising Future for DFU Treatment

While these preliminary results from a case series are encouraging, further research is needed to validate these findings scientifically. Well-designed controlled studies comparing Hyperoil™ to standard treatments are essential to confirm its efficacy and determine its optimal role in DFU management. However, this innovative approach offers hope for a more accessible, cost-effective, and patient-friendly way to manage a debilitating complication of diabetes.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.4172/2155-6156.1000499, Alternate LINK

Title: The Use Of A Mixture Of Hypericum Perforatum And Azadirachta Indica For The Management Of Diabetic Foot Ulcers: A Case Series

Subject: General Medicine

Journal: Journal of Diabetes & Metabolism

Publisher: OMICS Publishing Group

Authors: Maria Letizia Iabichella

Published: 2015-01-01

Everything You Need To Know

What were the main outcomes observed in the study that explored Hyperoil™ for treating diabetic foot ulcers?

The study indicates that using a mixture of Hypericum perforatum and Azadirachta indica, marketed as Hyperoil™, alongside well-managed diabetes care, led to the recovery of all 16 patients' diabetic foot ulcers (DFUs) within 2 to 10 months. Furthermore, the patients experienced improved HbA1c levels, elimination of pain related to DFUs, and better hypertension control. However, it's important to acknowledge the absence of a control group, which means we can't definitively say Hyperoil™ was solely responsible for the improvements.

What are Hypericum perforatum and Azadirachta indica, and what properties do they possess that might contribute to healing diabetic foot ulcers?

Hypericum perforatum, commonly known as St. John's Wort, and Azadirachta indica, known as Neem, are the two natural components of the Hyperoil™ mixture used in the study. Hypericum perforatum is often used for its potential wound-healing and anti-inflammatory properties, while Azadirachta indica has antibacterial and antiseptic qualities. Their combined action is believed to promote the healing of diabetic foot ulcers. Further studies are needed to confirm the individual and combined effects of these components.

What further research is recommended to validate the findings regarding Hyperoil™ and its effectiveness in managing diabetic foot ulcers?

While the case series demonstrated promising results in managing diabetic foot ulcers (DFUs) with Hyperoil™, it's crucial to conduct well-designed controlled studies comparing Hyperoil™ to standard treatments. These studies should involve larger patient groups and control groups to scientifically validate its effectiveness and determine its optimal role in DFU management. These studies will help to determine whether Hyperoil™ is more effective than existing treatments and understand the mechanisms through which it aids in healing.

What is the significance of improved HbA1c levels in the context of treating diabetic foot ulcers?

HbA1c levels reflect a person's average blood sugar levels over the past 2 to 3 months. In the context of diabetic foot ulcers (DFUs), improved HbA1c levels indicate better glycemic control, which is essential for healing. Uncontrolled blood sugar can impair the body's ability to heal wounds, making DFUs more severe and harder to treat. Therefore, managing HbA1c levels is an important part of the overall treatment strategy for DFUs, and the improvements seen in the study suggest a positive impact of Hyperoil™ on glycemic control.

What are the potential broader implications of poorly controlled diabetes and the development of diabetic foot ulcers on global health?

Poorly controlled diabetes can lead to several complications, one of the most severe being diabetic foot ulcers (DFUs). DFUs can result in infections, hospitalization, and even amputation in severe cases. The global prevalence of diabetes is increasing, with a projected doubling of cases by 2030, especially in developing nations. This highlights the urgent need for effective, accessible treatments like Hyperoil™ to prevent and manage DFUs, thus reducing the burden on patients, families, and healthcare systems.