Pigs receiving vaccinations with floating probiotics and zinc symbols.

Boost Your Pig's Immunity: Can Probiotics and Zinc Help Fight Swine Flu?

"New research explores how dietary supplements could enhance vaccine effectiveness and recovery in pigs facing influenza."


Swine influenza viruses (SIV) pose a persistent threat to pig populations worldwide, leading to significant economic losses for farmers. Unlike bacterial infections, there's no direct cure for viral infections like the flu. This has prompted research into preventative strategies, including dietary supplements that could boost the immune system.

Probiotics and zinc have long been recognized for their potential to bolster health. Probiotics, beneficial bacteria that promote gut health and modulate immune responses, and zinc, an essential mineral vital for numerous bodily functions, have shown promise in improving overall well-being. Given their individual benefits, scientists are exploring whether combining them with traditional vaccines could offer enhanced protection against SIV.

A recent study investigated the effects of Enterococcus faecium NCIMB 10415, a probiotic authorized for use in pig feed, and zinc oxide on pigs vaccinated against SIV. The findings reveal intriguing insights into how these supplements can influence the immune response, potentially paving the way for new strategies to combat swine flu and improve animal health.

Probiotics and Zinc: A One-Two Punch for Pig Immunity?

Pigs receiving vaccinations with floating probiotics and zinc symbols.

Researchers divided weaned piglets into groups, each receiving a different diet: one supplemented with E. faecium, another with varying levels of zinc oxide, and a control group. Half of the piglets in each dietary group were vaccinated against SIV. Later, all piglets were intentionally exposed to the H3N2 strain of SIV to assess the impact of the supplements on their immune response and overall health.

The results showed that piglets receiving E. faecium gained more weight before the viral challenge. Interestingly, after the infection, the E. faecium and high-zinc groups continued to gain weight, while the control group experienced weight loss, suggesting a faster recovery. Further analysis revealed:

  • Enhanced Antibody Response: Piglets in the E. faecium group that were also vaccinated exhibited significantly higher levels of H3N2-specific antibodies, particularly in the days leading up to and following the viral challenge. Higher hemagglutination inhibition (HI) titers, indicative of a stronger immune response, were also observed in the vaccinated E. faecium and high-zinc groups.
  • Immune Cell Activation: Flow cytometry analysis revealed increased activation of T helper cells and cytotoxic T lymphocytes in the E. faecium and high-zinc groups at specific points after infection, indicating a more robust cellular immune response.
  • Limited Impact on Viral Shedding and Lung Pathology: Despite the enhanced immune responses, the study found no significant differences in the amount of virus shed or the severity of lung lesions among the different dietary groups.
These findings suggest that while E. faecium and high-dose zinc oxide can boost the humoral immune response (antibody production) following vaccination and aid in recovery, they don't significantly reduce viral shedding or prevent lung damage.

What This Means for Pig Farmers

This research offers a promising avenue for enhancing swine flu prevention strategies. While not a standalone solution, supplementing pig diets with E. faecium and high-dose zinc oxide, particularly in conjunction with vaccination, could help bolster their immune systems and improve recovery from infection.

However, it's important to note that these supplements don't eliminate the virus or prevent lung damage. Good management practices, including maintaining sanitary conditions and ensuring proper ventilation, remain crucial in preventing and controlling swine flu outbreaks.

Further research is needed to fully understand the mechanisms behind these beneficial effects and to determine the optimal dosages and timing of supplementation. Nonetheless, these findings provide valuable insights into the potential of nutritional interventions to improve pig health and reduce the economic impact of swine influenza.

About this Article -

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This article is based on research published under:

DOI-LINK: 10.1371/journal.pone.0087007, Alternate LINK

Title: Dietary Enterococcus Faecium Ncimb 10415 And Zinc Oxide Stimulate Immune Reactions To Trivalent Influenza Vaccination In Pigs But Do Not Affect Virological Response Upon Challenge Infection

Subject: Multidisciplinary

Journal: PLoS ONE

Publisher: Public Library of Science (PLoS)

Authors: Zhenya Wang, Michael Burwinkel, Weidong Chai, Elke Lange, Ulrike Blohm, Angele Breithaupt, Bernd Hoffmann, Sven Twardziok, Juliane Rieger, Pawel Janczyk, Robert Pieper, Nikolaus Osterrieder

Published: 2014-01-28

Everything You Need To Know

1

What is the main health concern for pigs discussed?

Swine influenza, caused by Swine influenza viruses (SIV), is a significant concern for pig farmers worldwide. The virus leads to no direct cure, which means preventative strategies are critical to maintain pig health and reduce economic losses. This is why research focuses on enhancing the immune response and improving recovery after infection.

2

What is Enterococcus faecium and how does it help pigs?

The probiotic used in this study is Enterococcus faecium, specifically the strain NCIMB 10415. Probiotics like Enterococcus faecium are beneficial bacteria that promote gut health and modulate immune responses in pigs. The study showed that pigs receiving Enterococcus faecium gained more weight before the viral challenge, and those vaccinated with Enterococcus faecium exhibited higher levels of H3N2-specific antibodies. This suggests that Enterococcus faecium can enhance the immune response and improve overall health.

3

How does zinc oxide benefit pigs in this context?

The study uses zinc oxide as a dietary supplement. Zinc is an essential mineral for numerous bodily functions in pigs. The research indicates that the high-zinc group also showed a stronger immune response after vaccination against SIV, with higher hemagglutination inhibition (HI) titers. This indicates that zinc oxide, like Enterococcus faecium, can boost the immune system, improving the antibody response and aiding in recovery from swine flu.

4

What are the key implications of the study's findings for pig farmers?

The study's main finding is that supplementing pig diets with Enterococcus faecium and high-dose zinc oxide, in conjunction with vaccination, can enhance the humoral immune response (antibody production) and aid in recovery. It's important to note that while the supplements boosted the immune response, they did not significantly reduce viral shedding or prevent lung damage. The implications suggest that these supplements could become part of a comprehensive strategy to improve swine flu prevention and improve animal health.

5

What does the hemagglutination inhibition (HI) titer tell us, and why is it important in this study?

The hemagglutination inhibition (HI) titer measures the level of antibodies in the blood that can prevent the virus from causing an infection. Higher HI titers indicate a stronger immune response. In the study, the vaccinated E. faecium and high-zinc groups showed higher HI titers, indicating that these supplements enhanced the effectiveness of the vaccine. This is a crucial finding because it suggests that combining probiotics and zinc with vaccination can improve the immune system's ability to fight off swine flu.

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