A Tibetan child stands strong against TB, symbolizing hope and healing.

Tuberculosis Crisis: Unmasking the Alarming Prevalence in Tibetan Refugee Children

"A groundbreaking study reveals a hidden epidemic of TB among Tibetan children in India, urging immediate action and preventive strategies to safeguard this vulnerable population."


Tuberculosis (TB), a disease often associated with historical contexts, remains a significant global health threat, particularly for vulnerable populations. Each year, approximately one million children develop TB, and a quarter of a million succumb to the disease. Among those at disproportionate risk are Tibetan refugees in India, largely residing in the northern and southern states of Himachal Pradesh, Uttrakhand, and Karnataka. Studies have consistently indicated alarmingly high TB rates within these communities, with a considerable number of cases occurring in children.

The unique challenges faced by Tibetan refugees—including living in crowded conditions and socioeconomic barriers compounded by political marginalization—contribute significantly to this elevated TB burden. Past research has highlighted infection rates ranging from 65% to 98% among Tibetan immigrants in the United States and Canada. Recognizing the urgent need for intervention, a proactive campaign was initiated between 2011 and 2013, which identified a case prevalence of 394 per 100,000 among Tibetan schoolchildren in India. This alarming statistic underscores the necessity for targeted and effective strategies to combat TB within this high-risk group.

In response to the critical situation, the Zero TB Kids (ZTBK) initiative was launched, focusing on active TB case finding and preventive therapy programs in Tibetan schools across Northern India. This project aimed to screen and treat both TB disease and infection among schoolchildren and staff, adopting a community-based approach. This article presents the findings from the initiative’s first year, shedding light on the prevalence of TB and the effectiveness of intervention strategies within these communities.

Zero TB Kids Initiative: A Comprehensive Screening Program

A Tibetan child stands strong against TB, symbolizing hope and healing.

The Zero TB Kids (ZTBK) project, a collaborative effort between the Delek Hospital in Dharamsala, the Johns Hopkins University School of Medicine, the University of Wisconsin-Madison, and the Central Tibetan Administration (CTA), was launched to tackle the high rates of TB among Tibetan children. Gaining endorsement from spiritual and political leaders, the project conducted on-site screenings for active and latent TB in seven boarding and four day schools in Himachal Pradesh, India, from April 2017 to March 2018. The boarding schools, serving as homes for many children from impoverished families, provided a critical setting for intervention.

The screening process encompassed all students and staff, starting with a symptom review and testing for latent TB infection (LTBI). Anti-TB treatment was administered at a CTA-DOH facility. The study was deemed exempt by the Johns Hopkins Medicine Institutional Review Board and was approved by CTA-DOH, CTA-DOE, and school administrations. Parental consent was secured before any child received treatment, ensuring ethical standards were maintained throughout the initiative.

  • Comprehensive Screening: Every student and staff member was screened for TB symptoms and latent infections.
  • Ethical Oversight: The study was approved by multiple review boards, ensuring ethical compliance and safeguarding participant rights.
  • Collaborative Effort: Partnerships between hospitals, universities, and community organizations were crucial for the project's success.
The ZTBK initiative employed a detailed algorithm for screening active and latent TB. Basic demographic data, along with TB exposure history, were collected from school records. Additional information regarding index or source TB cases was obtained from the Department of Health. Contacts of TB cases were defined as individuals sharing living spaces or classrooms with diagnosed individuals. Standardized questionnaires were used to gather data on TB-related symptoms, past exposure, health conditions, and medication use. Each participant underwent examination by a project medical officer, with those exhibiting symptoms like prolonged cough (≥2 weeks) or other signs proceeding to further evaluation.

Moving Forward: Sustaining TB Control in Vulnerable Populations

The Zero TB Kids initiative offers valuable insights into addressing TB among vulnerable populations. The high rates of active and latent TB among Tibetan schoolchildren underscore the urgent need for targeted interventions. By leveraging community partnerships, comprehensive screening, and preventive treatments, TB control can be effectively implemented, protecting children and safeguarding public health. Future efforts should focus on sustaining these interventions, addressing challenges such as drug resistance, and expanding successful strategies to reach other at-risk communities worldwide.

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This article is based on research published under:

DOI-LINK: 10.1093/cid/ciy987, Alternate LINK

Title: High Prevalence Of Active And Latent Tuberculosis In Children And Adolescents In Tibetan Schools In India: The Zero Tb Kids Initiative In Tibetan Refugee Children

Subject: Infectious Diseases

Journal: Clinical Infectious Diseases

Publisher: Oxford University Press (OUP)

Authors: Kunchok Dorjee, Sonam Topgyal, Chungdak Dorjee, Tenzin Tsundue, Tenzin Namdol, Tenzin Tsewang, Tenzin Nangsel, Dekyi Lhadon, Tsering Choetso, Tenzin Dawa, Tenzin Phentok, Andrea N Deluca, Lobsang Tsering, Dawa Phunkyi, Tsetan D Sadutshang, Elizabeth J Bonomo, Zorba Paster, Richard E Chaisson

Published: 2018-11-20

Everything You Need To Know

1

What is the Zero TB Kids (ZTBK) initiative, and why was it started?

The Zero TB Kids (ZTBK) initiative is a collaborative project aimed at combating the high rates of Tuberculosis (TB) among Tibetan children in India. It was launched in response to alarming TB prevalence within the Tibetan refugee community. The initiative focuses on active TB case finding and preventive therapy programs in Tibetan schools. It involved screening and treating both active TB disease and latent TB infection (LTBI) among schoolchildren and staff, using a community-based approach to protect the vulnerable population.

2

What are the key findings regarding TB prevalence among Tibetan schoolchildren in India?

Studies have consistently indicated alarmingly high Tuberculosis (TB) rates among Tibetan schoolchildren in India. A proactive campaign between 2011 and 2013 found a case prevalence of 394 per 100,000 among Tibetan schoolchildren. The Zero TB Kids (ZTBK) initiative aimed to screen and treat both TB disease and latent TB infection (LTBI) among schoolchildren and staff, adopting a community-based approach.

3

Describe the screening process employed by the Zero TB Kids (ZTBK) initiative.

The Zero TB Kids (ZTBK) initiative employed a detailed algorithm for screening active and latent Tuberculosis (TB). The screening process encompassed all students and staff, starting with a symptom review and testing for latent TB infection (LTBI). Basic demographic data, along with TB exposure history, were collected from school records. Standardized questionnaires were used to gather data on TB-related symptoms, past exposure, health conditions, and medication use. Each participant underwent examination by a project medical officer, with those exhibiting symptoms like prolonged cough (≥2 weeks) or other signs proceeding to further evaluation.

4

What specific challenges do Tibetan refugees in India face that contribute to their elevated risk of Tuberculosis (TB)?

Tibetan refugees in India face unique challenges that significantly elevate their risk of Tuberculosis (TB). These include living in crowded conditions and socioeconomic barriers, compounded by political marginalization. These factors exacerbate the spread of Tuberculosis (TB) and complicate efforts to control the disease within this vulnerable population. Past research has highlighted infection rates ranging from 65% to 98% among Tibetan immigrants in the United States and Canada, emphasizing the need for immediate action and preventive strategies.

5

What is the importance of the Zero TB Kids (ZTBK) initiative's collaborative approach, and what are the next steps for sustaining TB control?

The Zero TB Kids (ZTBK) initiative's collaborative approach, involving Delek Hospital, Johns Hopkins University School of Medicine, University of Wisconsin-Madison, and the Central Tibetan Administration (CTA), was crucial for the project's success. It ensured comprehensive screening, ethical oversight, and effective interventions. Future efforts should focus on sustaining these interventions, addressing challenges such as drug resistance, and expanding successful strategies to reach other at-risk communities worldwide. By leveraging community partnerships, comprehensive screening, and preventive treatments, Tuberculosis (TB) control can be effectively implemented, protecting children and safeguarding public health.

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