Surgical techniques fitting together to heal a child's heart.

Tetralogy of Fallot: Is Valve-Sparing Repair Always the Best Option?

Soraya Malik in Health & Wellness December 2025 • 4 min read.

"Experts debate the optimal surgical approaches for Tetralogy of Fallot, weighing the benefits of valve-sparing techniques against potential long-term complications and the impact of valve biology."

Tetralogy of Fallot (ToF) is a complex congenital heart defect that requires surgical intervention. For years, surgeons have strived to refine their techniques to minimize the need for future operations and improve patient outcomes. One area of ongoing discussion is the role of valve-sparing repair, a surgical approach that aims to preserve the patient's pulmonary valve.

Valve-sparing repair has gained popularity due to its potential to avoid the complications associated with valve replacement, such as the need for lifelong anticoagulation. However, concerns remain about the long-term durability of the pulmonary valve after repair and the potential for progressive pulmonary regurgitation, a condition where blood leaks backward through the valve.

Recent letters to the editor of The Journal of Thoracic and Cardiovascular Surgery highlight the ongoing debate among experts regarding the optimal approach to ToF repair. These discussions focus on the technical aspects of valve-sparing techniques, the importance of valve biology, and the need for long-term follow-up to assess outcomes.

Intraoperative Balloon Dilation: A 'Secret Sauce' for ToF Repair?

Surgical techniques fitting together to heal a child's heart.

Drs. Vida and Stellin have been commended for their dedication to refining surgical techniques to reduce morbidity in pediatric cardiac surgery, particularly in the use of intraoperative balloon dilation during Tetralogy of Fallot (ToF) surgery. Their approach integrates intraoperative balloon dilation as one component of a comprehensive strategy for managing the pulmonary valve during ToF repair, often involving intricate plasty maneuvers, including surgical delamination of hypoplastic or dysplastic leaflets and patch reconstruction of damaged leaflets.

While another unit has mirrored this approach, employing similar balloon calibration techniques to expand the pulmonary annulus by 2 to 3 mm post-commissurotomy and balloon dilation, their long-term outcomes regarding reinterventions have not matched the results reported. This difference prompts questions about the variables influencing success in these procedures.

Technical Nuances: The size of the balloon and the aggressiveness of leaflet plasty maneuvers.
Study Design: Superior statistical design (matched cohort analysis) versus historical/retrospective data.
Wider Adoption: The limited number of centers reporting the use of this technique.

Emile A. Bacha suggests that it may be time to actively engage other centers, debate the technique in an open forum, and try to move the field forward.

Valve Biology vs. Surgical Technique: What Matters Most?

The long-term success of valve-sparing repair in ToF may depend on the interplay between surgical technique and the intrinsic biology of the pulmonary valve. While surgical interventions can acutely improve valve function, the long-term behavior of the valve may be influenced by factors such as valve morphology, the presence of dysplasia, and the potential for leaflet growth and remodeling.

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Everything You Need To Know

What is valve-sparing repair in the context of Tetralogy of Fallot (ToF) surgery, and what are its perceived advantages?

Valve-sparing repair in Tetralogy of Fallot (ToF) surgery is a surgical approach focused on preserving the patient's pulmonary valve during the repair of this complex congenital heart defect. The main advantage is avoiding complications associated with valve replacement, notably the need for lifelong anticoagulation. However, the durability of the pulmonary valve after valve-sparing repair and the potential for pulmonary regurgitation remain concerns, making it an area of debate among experts.

Why is there an ongoing debate about valve-sparing repair versus other surgical approaches for Tetralogy of Fallot (ToF)?

The debate surrounding valve-sparing repair for Tetralogy of Fallot (ToF) centers on balancing the immediate benefits of preserving the pulmonary valve against the potential for long-term complications. Specifically, there are concerns about the durability of the repaired pulmonary valve and the risk of developing pulmonary regurgitation, where blood leaks backward through the valve. Experts are actively discussing the technical nuances of valve-sparing techniques, the significance of valve biology, and the necessity for extended follow-up to accurately evaluate outcomes. The optimal surgical approach needs to consider these elements.

What factors might explain why some surgical units achieve better long-term outcomes with intraoperative balloon dilation during Tetralogy of Fallot (ToF) repair compared to others?

Differences in long-term outcomes with intraoperative balloon dilation during Tetralogy of Fallot (ToF) repair may stem from several factors. Technical nuances, such as the size of the balloon used and the intensity of leaflet plasty maneuvers, play a crucial role. Additionally, variations in study design, such as using matched cohort analysis versus historical data, can affect the assessment of outcomes. The limited number of centers reporting the use of this technique also contributes to the difficulty in standardizing and comparing results. The comprehensive approach by Drs. Vida and Stellin integrates intraoperative balloon dilation along with plasty maneuvers.

How does the biology of the pulmonary valve influence the success of valve-sparing repair in Tetralogy of Fallot (ToF) beyond the surgical technique?

The long-term success of valve-sparing repair in Tetralogy of Fallot (ToF) is intricately linked to the biology of the pulmonary valve. Factors such as the valve's morphology, the presence of dysplasia (abnormal tissue development), and the valve's capacity for growth and remodeling significantly affect long-term valve function. While surgical techniques can acutely improve valve function, the inherent biological characteristics of the valve can dictate its long-term behavior and resilience. This interplay between technique and biology is crucial for sustained positive outcomes.

What are Emile A. Bacha's suggestions for advancing the field of Tetralogy of Fallot (ToF) repair, particularly regarding valve-sparing techniques and intraoperative balloon dilation?

Emile A. Bacha suggests that to advance the field of Tetralogy of Fallot (ToF) repair, particularly concerning valve-sparing techniques and the use of intraoperative balloon dilation, active engagement with other centers is needed. He proposes open forums for debating the technique to encourage broader adoption and standardization. This collaborative approach aims to leverage collective experiences and insights, potentially improving outcomes and establishing best practices in ToF repair, and ultimately moving the field forward through shared knowledge and expertise.