A visual representation contrasting heart health risks between US and Swedish smokeless tobacco users.

Smokeless Tobacco: Is It Really a Safer Alternative?

"A deep dive into the latest research reveals surprising differences in heart health risks between U.S. and Swedish smokeless tobacco users."


For years, smokeless tobacco has been touted by some as a "safer" alternative to cigarettes. But is that really the case? The health effects of smokeless tobacco are of considerable research and public health interest. Globally, more than 300 million people use these products, many of them in low-income countries. In the USA, it has been estimated that smokeless tobacco use was responsible for approximately 1600 new cases of oral cancer, 500 new cases of pancreatic cancer and 200 new cases of oesophageal cancer in 2008.

A new systematic review and meta-analysis, published in Open Heart, is shedding light on the circulatory disease risks associated with smokeless tobacco use. This study offers an updated look at the potential dangers, particularly for users in Europe and North America. The aim of this study therefore is to produce an updated systematic review and meta-analysis of smokeless tobacco use and circulatory disease risks, specifically focusing on studies conducted among European and North American smokeless tobacco users. These regions were selected because products from these areas, such as chewing tobacco, moist snuff and snus, are commonly sold in the US market and thus regulated by the US Food and Drug Administration.

This article dives into the findings of this meta-analysis, exploring the differences in risk profiles between different regions and types of smokeless tobacco. We'll break down the key takeaways and what they mean for your heart health. Several reviews of smokeless tobacco use and circulatory disease risks have thus been published, but these reviews have varied in terms of the geographical areas and smokeless tobacco products they covered, the studies they included and the findings they reported.

The Great Divide: US vs. Swedish Smokeless Tobacco

A visual representation contrasting heart health risks between US and Swedish smokeless tobacco users.

The meta-analysis, encompassing 17 cohort studies, 5 case-control studies, one cross-sectional analysis, and two pooled data analyses, revealed a striking contrast between US and Swedish smokeless tobacco users. Researchers found that US smokeless tobacco users faced a significantly increased risk of heart disease and stroke. Meta-analysis results did not show increased risk of heart disease or stroke among smokeless tobacco users in Sweden compared with non-users, but did show increased heart disease and stroke risk for US smokeless tobacco users. These US results were consistent for current smokeless tobacco users compared with never tobacco users and for former smokers who had switched to smokeless tobacco use compared with former smokers who had quit tobacco use entirely.

Specifically:

  • Heart Disease: US users showed a 17% increased risk (Relative Risk (RR) 1.17, 95% CI 1.09 to 1.27).
  • Stroke: US users had a 28% increased risk (RR 1.28, 95% CI 1.01 to 1.62).
  • Swedish Snus: No increased risk of heart disease or stroke was observed among Swedish snus users.
Why the discrepancy? The study points to differences in product characteristics and usage patterns. US smokeless tobacco products are known to contain varying levels of numerous constituents including nicotine, tobacco-specific nitrosamines (TSNAs) such as the carcinogens NNN and NNK, anions such as nitrite, nitrate and chloride, polycyclic aromatic hydrocarbons such as benzo[a]pyrene and volatile aldehydes such as formaldehyde. Swedish snus products, in contrast, are subject to a quality control standard known as GothiaTek that sets maximum limits on product constituents including TSNAs, nitrite, benzo[a] pyrene and metals.

What This Means for You

If you're a smokeless tobacco user in the US, this study serves as a stark reminder of the potential dangers to your heart health. The increased risk of heart disease and stroke is significant, and highlights the need for informed decisions about tobacco use.

While Swedish snus may present a different risk profile, it's crucial to remember that no tobacco product is entirely risk-free. several studies comparing constituent levels, use patterns and other characteristics of smokeless tobacco use across product types could help further strengthen our knowledge of the health risks of smokeless tobacco products.

Ultimately, the best course of action for your health is to quit all tobacco use. Talk to your doctor about cessation strategies and resources available to help you break free from tobacco's grip. Practitioner's should advise their patients who use smokeless tobacco products of the known health risks and provide advice on cessation.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1136/openhrt-2018-000846, Alternate LINK

Title: Smokeless Tobacco Use And Circulatory Disease Risk: A Systematic Review And Meta-Analysis

Subject: Cardiology and Cardiovascular Medicine

Journal: Open Heart

Publisher: BMJ

Authors: Brian L Rostron, Joanne T Chang, Gabriella M Anic, Manju Tanwar, Cindy M Chang, Catherine G Corey

Published: 2018-10-08

Everything You Need To Know

1

What is smokeless tobacco, and why is it important?

Smokeless tobacco is a type of tobacco product that is not smoked. It comes in various forms, including chewing tobacco, moist snuff, and snus. The study focuses on the health effects of smokeless tobacco, particularly its impact on heart health. The importance lies in the fact that this product is used by a large global population, making it a public health concern. The article highlights how this product can cause increased risks of heart disease and stroke among US users, contrasting with the Swedish product.

2

What is a meta-analysis, and what role did it play in this study?

A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. In this context, the meta-analysis combines data from 17 cohort studies, 5 case-control studies, one cross-sectional analysis, and two pooled data analyses. This allows researchers to draw more robust conclusions about the relationship between smokeless tobacco use and health outcomes, specifically circulatory disease risks. By analyzing a larger pool of data, the findings provide a more comprehensive understanding of the risks involved.

3

What were the key findings regarding the impact of US smokeless tobacco on heart health?

In the study, US smokeless tobacco users exhibited an increased risk of both heart disease (17% increase, Relative Risk (RR) 1.17) and stroke (28% increase, RR 1.28). These findings suggest a significant health risk associated with the use of US smokeless tobacco products. The implications are serious: users face a higher likelihood of developing heart disease or experiencing a stroke. This underscores the need for awareness and caution regarding these products.

4

What is Swedish snus, and how does its impact on heart health compare to that of US smokeless tobacco?

Swedish snus is a specific type of smokeless tobacco product used in Sweden. The study found no increased risk of heart disease or stroke among Swedish snus users. This contrasts sharply with the increased risks observed among US smokeless tobacco users. The key difference is the product characteristics, including the regulation differences. Swedish snus products are subject to strict quality control standards (GothiaTek) which limits harmful constituents such as TSNAs. This explains why the Swedish product is shown to be safer.

5

What explains the difference in heart health risks between US and Swedish smokeless tobacco users?

The disparity in heart health risks between US and Swedish smokeless tobacco users is primarily attributed to differences in product characteristics and usage patterns. US products may contain varying levels of harmful constituents such as nicotine, tobacco-specific nitrosamines (TSNAs), and others. Conversely, Swedish snus is subject to the GothiaTek quality control standard, which limits the levels of harmful substances. These differences have significant implications for user health, highlighting the importance of product regulation and the potential impact on cardiovascular health outcomes.

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