Before and after tear trough correction with autologous fibroblast and keratin filler.

Say Goodbye to Tired Eyes: A Revolutionary Filler for Tear Trough Deformity

Lena Kashyap in Health & Wellness December 2025 • 4 min read.

"Discover the innovative autologous fibroblast and keratin filler offering long-lasting, natural-looking results for tear trough correction."

The quest for youthful and refreshed eyes has led to numerous cosmetic innovations. Among the most persistent concerns is the tear trough deformity, the hollowing and shadowing under the eyes that contributes to a perpetually tired or aged appearance. While various treatments exist, the search for a safe, effective, and long-lasting solution continues.

Traditional methods range from surgical options like blepharoplasty to injectable fillers. However, surgery carries inherent risks, and conventional fillers often require repeated treatments. A promising new approach is emerging: autologous fibroblasts combined with keratin. This innovative filler utilizes your own cells, minimizing the risk of adverse reactions and potentially offering more enduring results.

This article will explore the science behind this cutting-edge filler, drawing from recent research evaluating its effectiveness and safety. We'll delve into how autologous fibroblasts and keratin work together to correct tear trough deformity, providing you with a comprehensive understanding of this revolutionary treatment option.

The Science Behind the Solution: Autologous Fibroblasts and Keratin

Before and after tear trough correction with autologous fibroblast and keratin filler.

The new injectable soft tissue filler consists of autologous fibroblasts and keratin gel. Autologous simply means that the substances are derived from the same individual who is receiving the filler, drastically minimizing risks.

Here's a breakdown of the key components and how they contribute to tear trough correction:

Autologous Fibroblasts: These are cells naturally present in your skin that are responsible for producing collagen, the protein that provides structure and elasticity. By injecting fibroblasts, the treatment aims to stimulate collagen production in the tear trough area, restoring volume and smoothing out the hollow.
Keratin Gel: Keratin is a fibrous protein that provides structural support to skin, hair, and nails. In this filler, keratin acts as a scaffold, providing a framework for the fibroblasts to attach to and produce collagen. It also contributes to the initial filling effect while the fibroblasts begin to work.

The process begins with a small skin biopsy, typically taken from behind the ear to minimize scarring. The fibroblasts are then extracted and cultured in a lab, increasing their numbers. Simultaneously, keratin is extracted from a sample of your hair. The fibroblasts and keratin are then combined into an injectable gel.

Lasting Results and Minimal Risks

A study published in Aesthetic Plastic Surgery demonstrated the effectiveness and safety of this autologous fibroblast and keratin filler for tear trough correction. The study followed 35 patients who received the treatment, assessing their clinical features, satisfaction levels, and photographic evidence over 24 months.

The results showed significant improvement in tear trough deformity, even at 18-24 months post-injection. Importantly, no severe adverse effects were observed. Patients reported high satisfaction levels, and the effects were sustained over a significant period, suggesting a long-term solution.

The combination of autologous fibroblasts and keratin offers a promising new avenue for individuals seeking to address tear trough deformity. Its unique approach, utilizing the body's own cells and structural proteins, suggests a safe, effective, and long-lasting solution for achieving a refreshed and youthful appearance.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1007/s00266-018-1259-y, Alternate LINK

Title: Correction Of Tear Trough Deformity Using Autologous Fibroblast Combined With Keratin: New Soft Tissue Filler

Subject: Surgery

Journal: Aesthetic Plastic Surgery

Publisher: Springer Science and Business Media LLC

Authors: Wenshan Xing, Chen Zhang, Jiao Zhang, Qingguo Zhang

Published: 2018-11-19

Everything You Need To Know

How does the autologous fibroblast and keratin filler actually correct tear trough deformity?

The autologous fibroblast and keratin filler works by utilizing your own skin cells (autologous fibroblasts) to stimulate collagen production in the tear trough area. The keratin gel acts as a scaffold, providing a framework for the fibroblasts to attach to and produce collagen. This combination restores volume, smooths out hollows, and reduces the appearance of shadowing under the eyes.

What are the advantages of using autologous fibroblast and keratin filler compared to traditional fillers or surgery for tear troughs?

Traditional fillers often require repeated treatments, and surgical options like blepharoplasty carry inherent risks. The autologous fibroblast and keratin filler offers a potentially longer-lasting solution with minimal risks because it uses your own cells, reducing the chance of adverse reactions. This approach aims to provide a more enduring and natural-looking correction of tear trough deformity compared to conventional methods.

Can you describe the process of creating the autologous fibroblast and keratin filler for tear trough correction?

The procedure involves taking a small skin biopsy, usually from behind the ear, to extract autologous fibroblasts. Keratin is extracted from a hair sample. The fibroblasts are then cultured in a lab to increase their numbers. Finally, the cultured fibroblasts and keratin are combined into an injectable gel, ready for tear trough correction.

What evidence supports the effectiveness of autologous fibroblast and keratin filler for tear trough correction?

The study published in *Aesthetic Plastic Surgery* followed 35 patients over 24 months after receiving the autologous fibroblast and keratin filler. The study assessed clinical features, satisfaction levels, and photographic evidence, demonstrating the effectiveness and safety of this approach for tear trough correction. However, the specific quantitative results (e.g., average reduction in tear trough depth, percentage of patients reporting satisfaction) are not detailed here and would need to be obtained from the original study.

Beyond tear trough deformity, could the autologous fibroblast and keratin approach be used for other cosmetic applications?

While the text focuses on the use of autologous fibroblasts and keratin for tear trough deformity, the underlying principle of using autologous cells and supportive scaffolds could potentially be applied to other areas of the face or body where volume loss or collagen stimulation is desired. For example, it might be adapted for addressing wrinkles, fine lines, or even for subtle volume enhancement in other facial areas. However, further research and development would be necessary to optimize the specific formulations and techniques for different applications.