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Pulp Capping Materials: Are We Using the Best Ones?

"A deep dive into the latest research on long-term clinical effectiveness of pulp-capping materials and what it means for your dental health."


For years, the standard approach when a dental pulp was exposed involved a pulpectomy, which basically meant removing the pulp. The thinking was that once exposed, the pulp couldn't recover. But, in 1989, a groundbreaking report by Stanley revealed the dental pulp has regenerative abilities, suggesting that saving the pulp is possible.

This led to vital pulp therapy, including direct pulp capping (DPC), to preserve pulp tissue when exposure occurred due to cavities, trauma, or accidents during dental procedures. Direct pulp capping involves placing a protective material directly over the exposed pulp to encourage healing and maintain the tooth’s vitality.

Many materials have been used for DPC, but figuring out which one works best has been an ongoing question. To get some clarity, a review was conducted to assess the clinical success of different DPC materials based on reliable studies with long-term follow-up. The goal is to recommend the most effective materials for direct pulp capping, ensuring better outcomes and lasting dental health.

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Why Pulp Capping Matters

Pulp capping is intended to protect a tooth's dental pulp when it is exposed or nearly exposed during cavity preparation, trauma, or treatment of a deep cavity. Its broader impact is the possibility of preserving pulp vitality and avoiding more extensive treatment, although outcomes depend on the clinical circumstances. Because no statistics were provided for this subsection, the scale of its use and success cannot be quantified here.

Conventional Pulp-Capping Methods

Direct pulp capping places a dental biomaterial directly over an exposed pulp to promote healing and formation of a mineralized tissue barrier. When successful, the procedure can preserve pulp vitality and avoid further, more extensive treatment. Both direct and indirect pulp capping are described as techniques intended to preserve vitality and promote dentin-bridge formation, but their indications, materials, procedures, and clinical outcomes must be considered when selecting an approach.

From Gold Foils to Modern Materials

The first described method of capping an exposed pulp used gold foils and was attributed to Pfaff in 1756. Until the end of the nineteenth century, many direct pulp-capping agents were used empirically, based on the idea that irritation from etching or cauterization could stimulate healing. Later, greater attention shifted toward disinfecting agents and other approaches to managing the exposed pulp.

MTA vs. Calcium Hydroxide: Which Pulp Capping Material Offers Better Long-Term Success?

Advanced dental materials protecting a tooth.

When it comes to direct pulp capping, two materials have been studied extensively: mineral trioxide aggregate (MTA) and calcium hydroxide (CH). A recent review analyzed numerous studies to compare their long-term effectiveness.

The review included 15 articles that met specific criteria, covering 1,322 teeth treated with 12 different DPC materials. Of these, 1,136 teeth were evaluated at the final follow-up. Key findings revealed that while the number of studies, treated teeth, and average follow-up periods were similar for both MTA and calcium hydroxide, MTA showed superior success rates.

  • Calcium Hydroxide (CH): CH has been a staple in dental practice since the 1920s, thanks to its high pH, which helps kill bacteria and promote dentin bridge formation. However, CH has drawbacks: its high pH can irritate the pulp, potentially leading to inflammation and necrosis. It can also cause tunnel defects in the dentin bridge and degrade over time, jeopardizing the long-term seal.
  • Mineral Trioxide Aggregate (MTA): Developed in 1993, MTA is a calcium silicate-based cement known for reducing pulpal inflammation and promoting predictable hard tissue formation. Studies show it results in less inflammation and more reliable hard tissue formation compared to CH.
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What Recent Evidence Examines

Recent research has evaluated direct pulp capping as a conservative vital pulp therapy in permanent teeth. A study using New York health-insurance data from 2006 to 2019 followed 4,136 unique teeth that received direct pulp capping and reported treatment outcomes in permanent teeth. The same evidence identified adequate tooth isolation as a significant prognostic factor, while newer systematic work is comparing the clinical effectiveness of different materials with follow-up duration included as a covariate.

Why Outcomes Can Vary

Direct pulp capping is presented as a procedure for safeguarding and revitalizing pulp exposed through trauma or decay. Its suitability therefore depends on the clinical situation surrounding the exposure rather than on the procedure's label alone. The available source for this subsection does not provide a failure rate or a detailed comparison of unsuccessful outcomes, so no specific estimate can be stated.

Materials and Treatment Choices

Direct and indirect pulp capping are among therapies aimed at pulp healing and regeneration, while other treatment options include vital amputation, treatment of infected non-vital teeth, and pulp regeneration. In direct pulp capping, the material choice can influence treatment outcomes; calcium silicate-based materials such as mineral trioxide aggregate and Biodentine are described as promising alternatives to traditional materials. For carious pulp exposure in mature teeth, a source reports high success rates for both direct pulp capping and partial pulpotomy, while emphasizing careful case selection and an excellent coronal seal.

Despite MTA’s promising results, it's not without its challenges. MTA can cause tooth discoloration and has a long setting time, which can be inconvenient. Newer materials like Biodentine and Endocem aim to overcome these limitations.

The Future of Pulp Capping: What's Next?

While the review suggests MTA is more effective and predictable than calcium hydroxide, the results are based on studies with a high risk of bias. More high-quality, long-term clinical trials are needed to confirm these findings and explore the potential of newer materials like Biodentine and Endocem. Ultimately, the goal is to provide dental professionals with the best tools for preserving tooth vitality and ensuring optimal patient outcomes.

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Does the Material Decide the Outcome?

A systematic review and meta-analysis examined direct pulp capping in mature permanent teeth with a cariously exposed pulp and a clinical diagnosis of reversible pulpitis. Its stated objective included determining whether the capping material influences the outcome. Another systematic review and meta-analysis compared the effectiveness of biomaterials and techniques used to protect exposed tissues and induce repair through a mineralized barrier. These sources support evaluating both material choice and technique rather than assuming that one material is universally best.

Toward Vital Pulp Preservation

Future-oriented discussions place vital pulp treatment within strategies focused on preserving pulp tissue in vital teeth with deep caries and exposed pulp. Indirect and direct pulp capping have been described as therapies for carious teeth for over a century, while newer material-focused discussions highlight Biodentine and vital pulp therapy as part of tooth-preservation efforts. The direction of the field therefore combines established pulp-preservation procedures with continued interest in bioactive materials and alternatives to root canal therapy.

The Broader Clinical Setting

Pulp-capping decisions occur within the wider challenge of preserving natural teeth while managing deep decay and pulp exposure. The appropriate choice can depend on the condition of the pulp, the extent of the lesion, and the ability to provide reliable restorative care. Because no sources were provided for this subsection, broader system-level barriers and population-level effects cannot be described more specifically.

Preserving a Developing Tooth

Managing deep carious lesions in an immature tooth while preserving pulp vitality is described as a real challenge in daily dental practice. The reported case used a bioactive cement, reflecting clinical interest in materials that may support treatment in such situations. This example shows how pulp capping can be especially consequential when maintaining vitality is important during tooth development.

What the review can and cannot establish

The review points toward MTA performing better than CH across the included evidence, but it does not establish that MTA is best for every pulp-exposed tooth: the underlying studies were judged at high risk of bias.[1]

Because most of the other materials had only limited study coverage, the comparison is more informative for MTA and CH than for the broader range of capping options.[1]

What keeps this material comparison unsettled

  • All included studies were judged to have a high risk of bias, which weakens confidence in the apparent advantage.[1]
  • Most materials beyond the leading comparison were examined in only a small number of studies.[1]
  • The review calls for longer-term clinical and radiographic studies designed to reduce bias.[1]

A long-term review of clinical and radiographic pulp-capping outcomes

PopulationHuman pulp-exposed teeth[1]
Sample size1,322 teeth were treated; 1,136 teeth were evaluated at final follow-up[1]
Main outcomeClinical and radiographic effectiveness of direct pulp-capping materials[1]
Effect sizeMTA success rates were superior to CH[1]
Times cited16[1]

How this review fits with later comparisons

The review’s MTA-over-CH finding is consistent with a later cited meta-analysis reporting that the gap between the materials widened over time, with odds ratios rising from 2.22 at six months to 3.00 at three years.[1] [2]

A separate trial reported higher cumulative survival for MTA than CH at 36 months, while another cited study found no significant clinical-success difference between Biodentine and MTA; these results concern different comparisons and settings.[3] [4]

About this Article -

Written with AI assistance from published research, and reviewed by the Mystum team. See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.2334/josnusd.18-0125, Alternate LINK

Title: Long-Term Clinical And Radiographic Evaluation Of The Effectiveness Of Direct Pulp-Capping Materials

Subject: General Dentistry

Journal: Journal of Oral Science

Publisher: Nihon University School of Dentistry

Authors: Takashi Matsuura, Viviane K. S. Kawata-Matsuura, Shizuka Yamada

Published: 2019-01-01

Everything You Need To Know

1

What is direct pulp capping (DPC), and why is it used in dentistry?

Direct pulp capping (DPC) is a vital pulp therapy technique used to preserve pulp tissue when exposure occurs due to cavities, trauma, or dental procedure accidents. It involves placing a protective material directly over the exposed pulp to encourage healing and maintain the tooth’s vitality. This approach became popular following a 1989 report by Stanley, which revealed the regenerative abilities of dental pulp, challenging the traditional approach of pulpectomy (pulp removal) for exposed pulps.

2

How do mineral trioxide aggregate (MTA) and calcium hydroxide (CH) compare as pulp-capping materials?

Mineral trioxide aggregate (MTA) and calcium hydroxide (CH) are two extensively studied materials for direct pulp capping. Calcium hydroxide (CH) has been used since the 1920s due to its high pH, which helps kill bacteria and promote dentin bridge formation. However, CH can irritate the pulp, potentially leading to inflammation and necrosis. It may also cause tunnel defects in the dentin bridge and degrade over time. Mineral trioxide aggregate (MTA), developed in 1993, is a calcium silicate-based cement known for reducing pulpal inflammation and promoting predictable hard tissue formation. Studies suggest MTA results in less inflammation and more reliable hard tissue formation compared to CH. A recent review suggests MTA shows superior success rates.

3

What are the limitations of using mineral trioxide aggregate (MTA) in pulp capping, and what alternative materials are being explored?

While mineral trioxide aggregate (MTA) has shown promising results in direct pulp capping, it is not without its challenges. MTA can cause tooth discoloration and has a long setting time, which can be inconvenient for dental procedures. Due to these limitations, newer materials like Biodentine and Endocem are being explored as alternatives. These materials aim to overcome MTA's drawbacks while maintaining or improving its effectiveness in promoting pulp healing and hard tissue formation.

4

What are the potential drawbacks of using calcium hydroxide (CH) for direct pulp capping, and how might these affect the long-term success of the treatment?

Although calcium hydroxide (CH) has been a long-standing material in dental practice for direct pulp capping due to its antibacterial properties and ability to promote dentin bridge formation, it has several potential drawbacks that can affect the long-term success of the treatment. One major concern is that its high pH can irritate the pulp, potentially leading to inflammation and necrosis. Additionally, CH can cause tunnel defects in the dentin bridge and degrade over time, which may jeopardize the long-term seal and increase the risk of treatment failure. These limitations have prompted the search for alternative materials like MTA.

5

What future research is needed to determine the best pulp-capping materials for ensuring optimal patient outcomes and preserving tooth vitality?

Future research should focus on conducting more high-quality, long-term clinical trials to confirm the findings that mineral trioxide aggregate (MTA) is more effective than calcium hydroxide (CH). These trials should also explore the potential of newer materials like Biodentine and Endocem. Additionally, research should aim to reduce bias and provide dental professionals with the best tools for preserving tooth vitality and ensuring optimal patient outcomes. Further investigation should explore the mechanisms by which these materials interact with pulp tissue at a cellular and molecular level.

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