Stylized heart with glowing electrical pathways representing TAVR risk prediction.

Pacemaker Implantation After TAVR: How to Reduce Your Risk

"A new model helps predict and potentially avoid the need for pacemakers after transcatheter aortic valve replacement."


Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic stenosis, offering a less invasive alternative to traditional open-heart surgery. While TAVR has shown remarkable success, one of the significant complications following the procedure is the need for permanent pacemaker implantation (PPI). This necessity arises because TAVR can sometimes damage the heart's electrical conduction system.

Researchers and cardiologists have been working diligently to identify the factors that increase the risk of PPI after TAVR. Understanding these factors is crucial for refining patient selection, optimizing procedural techniques, and ultimately reducing the incidence of this complication. This article delves into a recent study that proposes a predictive model to assess the risk of PPI following TAVR, offering new insights into how clinicians can better manage this aspect of patient care.

The original research, published in the JACC: Cardiovascular Imaging journal, has sparked discussions within the medical community. This article aims to translate the complex findings of this study into an accessible format, providing clear takeaways for patients, their families, and healthcare professionals. By understanding the key elements of this predictive model, individuals can engage in more informed conversations with their doctors about the risks and benefits of TAVR.

What Factors Increase Pacemaker Risk After TAVR?

Stylized heart with glowing electrical pathways representing TAVR risk prediction.

A recent study highlighted in the JACC: Cardiovascular Imaging journal has identified three critical factors that significantly influence the need for pacemaker implantation after TAVR. These factors provide a more nuanced understanding of the risks involved and can help doctors make more informed decisions. Let's break down these key elements:

The cutpoints generated by the model were 7.75 mm for membranous septum length and 17.3 mm³ for noncoronary cusp device landing zone calcium volume (with an 850 Hounsfield Unit threshold for detection). Importantly, these thresholds were derived from a predictive model in a single-center analysis (Cedars-Sinai Heart Institute) and so absolute cutoffs should not at this stage drive clinical management, although they could be used for comparison in prospective studies.

  • Membranous Septum Length: The length of the membranous septum, a thin portion of tissue in the heart, plays a critical role. Shorter membranous septum lengths are associated with a higher risk of PPI after TAVR. This is because a shorter septum offers less protection to the heart's electrical pathways during the valve replacement procedure.
  • Noncoronary Cusp Device Landing Zone Calcium Volume: The amount of calcium in the noncoronary cusp, where the TAVR device lands, is another important factor. Higher volumes of calcium increase the risk of conduction disturbances, leading to the need for a pacemaker. The presence of calcium can interfere with the heart's normal electrical activity.
  • Baseline Conduction: The patient's pre-existing electrical conduction status is also significant. Patients with pre-existing conduction abnormalities are more likely to require a pacemaker after TAVR. This is because the TAVR procedure can exacerbate existing issues with the heart's electrical system.
These three factors—membranous septum length, noncoronary cusp calcium volume, and baseline conduction—provide a comprehensive view of the risks associated with PPI after TAVR. By evaluating these elements before the procedure, doctors can better assess a patient's individual risk profile and tailor their approach accordingly. The measurement of the membranous septum was based on a 2-dimensional measurement in a coronal plane, as for the original description by Hamdan et al. (2), and this parameter may be further optimized in future with a 3-dimensional methodology. It should also be noted that we have made considerable efforts to standardize calcium quantification in contrast computed tomography scans (3), but the methodology used has only been validated in a single-center study in 1 post-processing software package, albeit with a robust correlation to Agatston score from noncontrast scans and also to the endpoint of paravalvular leak (3).

Moving Forward: Refining TAVR Practices

The insights from this study are a stepping stone toward more refined TAVR practices. The predictive model offers a framework for further research and collaboration, with the ultimate goal of improving clinical decision-making. As TAVR technology and techniques continue to advance, a comprehensive understanding of these risk factors will be essential for optimizing patient outcomes and minimizing complications. Lastly, there may be device differences in parameters and procedural differences (including implant depth, pre-dilatation, and post-dilatation).

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1097/dcr.0000000000000873, Alternate LINK

Title: The Authors Reply

Subject: Gastroenterology

Journal: Diseases of the Colon & Rectum

Publisher: Ovid Technologies (Wolters Kluwer Health)

Authors: Kerollos Nashat Wanis, Christopher Vinden

Published: 2017-09-01

Everything You Need To Know

1

Why is a pacemaker sometimes needed after TAVR?

The need for a permanent pacemaker implantation (PPI) after Transcatheter Aortic Valve Replacement (TAVR) can arise because the TAVR procedure sometimes damages the heart's electrical conduction system. This damage disrupts the normal flow of electrical signals that regulate the heartbeat. This outcome is significant because it can affect a patient's quality of life, necessitating ongoing medical management and potentially impacting physical activity levels.

2

What is the significance of the membranous septum length in the context of TAVR?

The membranous septum length is a crucial factor. A shorter membranous septum increases the risk of Pacemaker Implantation (PPI) after TAVR. This is because the membranous septum is a thin part of the heart, and its length offers protection to the heart's electrical pathways during the TAVR procedure. A shorter length provides less protection, making these pathways more vulnerable to damage from the TAVR procedure, increasing the likelihood of needing a pacemaker.

3

How does the amount of calcium in the noncoronary cusp affect the need for a pacemaker after TAVR?

The volume of calcium in the noncoronary cusp device landing zone is another key factor. A higher volume of calcium in this area increases the risk of Pacemaker Implantation (PPI) after Transcatheter Aortic Valve Replacement (TAVR). Calcium can interfere with the heart's normal electrical activity, which is essential for proper heart function. This interference can lead to conduction disturbances, necessitating the need for a pacemaker to regulate the heart's rhythm.

4

What does baseline conduction mean in the context of TAVR, and why is it important?

Baseline conduction refers to a patient's pre-existing electrical conduction status before Transcatheter Aortic Valve Replacement (TAVR). If a patient has pre-existing conduction abnormalities, they are more likely to require a pacemaker after TAVR. The TAVR procedure can exacerbate any existing issues within the heart's electrical system. Recognizing pre-existing conduction issues allows doctors to assess and manage the patient's risk factors, helping them make informed decisions about the procedure.

5

What is the main goal of the study mentioned, and what are its key findings regarding TAVR?

A recent study in *JACC: Cardiovascular Imaging* journal proposes a predictive model to assess the risk of Pacemaker Implantation (PPI) following TAVR, providing insights into clinical decision-making. The model identified Membranous Septum Length, Noncoronary Cusp Device Landing Zone Calcium Volume, and Baseline Conduction as critical factors. By understanding these factors, individuals can have informed discussions with their doctors regarding the risks and benefits of TAVR, potentially leading to better patient outcomes.

Newsletter Subscribe

Subscribe to get the latest articles and insights directly in your inbox.