Illustration symbolizing the connection between inflammation, blood vessels, and potential cancer risk.

Inflammation's Hidden Link: Can a Simple Blood Test Predict Your Cancer Risk?

Elliot Brynn in Health & Wellness August 2025 • 4 min read.

"Research reveals how high-sensitivity C-reactive protein (hs-CRP) levels could signal increased cancer mortality in heart patients, prompting earlier detection strategies."

Inflammation is your body's natural response to injury or infection. However, when inflammation becomes chronic, it can contribute to a range of diseases, including cardiovascular issues and even cancer. High-sensitivity C-reactive protein (hs-CRP) is a key marker of inflammation in the body, easily measured through a routine blood test.

While the link between inflammation and cardiovascular disease is well-established, emerging research suggests that inflammation, as indicated by elevated hs-CRP, might also play a significant role in cancer development and progression. Understanding this connection is crucial for identifying individuals at higher risk and implementing preventative measures.

This article explores the findings of a recent study investigating the long-term impact of hs-CRP levels on cancer mortality in patients with stable coronary artery disease (CAD). We'll break down the research, explain what it means for your health, and discuss how hs-CRP testing could become a valuable tool in proactive healthcare.

Hs-CRP: An Early Warning Sign for Cancer?

Illustration symbolizing the connection between inflammation, blood vessels, and potential cancer risk.

A retrospective study published in the Circulation Journal analyzed data from 2,867 patients with stable CAD who underwent percutaneous coronary intervention (PCI), a procedure to open blocked arteries. Researchers divided patients into two groups based on their hs-CRP levels: those with levels below 0.10 mg/dL and those with levels at or above this threshold.

Over a median follow-up period of 5.8 years, the study revealed a significant association between elevated hs-CRP and increased cancer mortality. Key findings included:

Patients with hs-CRP levels of 0.10 mg/dL or higher had a significantly higher incidence of both all-cause mortality and cancer death compared to those with lower hs-CRP levels.
Multivariable analysis showed that higher hs-CRP was independently associated with a greater risk of cancer death, even after adjusting for other risk factors like age, smoking, and kidney disease.
Specifically, elevated hs-CRP was linked to increased deaths from gastrointestinal and lung cancers.

These results suggest that hs-CRP measurement could be a useful tool for identifying individuals with stable CAD who are at an increased risk of cancer death. This early identification could lead to more proactive screening and preventative strategies.

Taking Control of Your Health: What This Means for You

The study highlights the importance of understanding the link between inflammation and overall health, particularly for individuals with existing cardiovascular conditions. While hs-CRP is not a direct indicator of cancer, elevated levels can serve as a warning sign, prompting further investigation and proactive health management.

If you have stable coronary artery disease or other risk factors for heart disease, talk to your doctor about getting your hs-CRP levels checked. Discuss lifestyle modifications, such as diet and exercise, that can help reduce inflammation. Early detection and intervention are key to improving long-term health outcomes.

This research encourages a more holistic approach to healthcare, where inflammation is recognized as a critical factor influencing multiple aspects of health, including cancer risk. By monitoring hs-CRP levels and addressing underlying inflammation, individuals can take proactive steps to protect their well-being.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1253/circj.cj-18-0962, Alternate LINK

Title: Long-Term Predictive Value Of High-Sensitivity C-Reactive Protein For Cancer Mortality In Patients Undergoing Percutaneous Coronary Intervention

Subject: Cardiology and Cardiovascular Medicine

Journal: Circulation Journal

Publisher: Japanese Circulation Society

Authors: Hirohisa Endo, Tomotaka Dohi, Takehiro Funamizu, Jun Shitara, Hideki Wada, Shinichiro Doi, Ryo Naito, Hirokazu Konishi, Manabu Ogita, Hiroshi Iwata, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Kazunori Shimada, Katsumi Miyauchi, Hiroyuki Daida

Published: 2019-02-25

Everything You Need To Know

What is the connection between inflammation and cancer?

Inflammation is the body's natural response to injury or infection. Elevated levels of hs-CRP, a key marker of inflammation, have been associated with increased cancer mortality in individuals with stable CAD. The study revealed that patients with hs-CRP levels of 0.10 mg/dL or higher experienced a significantly higher incidence of both all-cause mortality and cancer death. This suggests that chronic inflammation, as indicated by hs-CRP, may contribute to the development and progression of cancer. The implications include the potential for earlier detection of cancer risk and the implementation of preventative measures.

What is hs-CRP and why is it significant?

Hs-CRP, or high-sensitivity C-reactive protein, is a protein produced by the liver in response to inflammation. A simple blood test can measure hs-CRP levels. In the context of this study, hs-CRP served as a marker of inflammation. The study found a significant correlation between elevated hs-CRP levels (0.10 mg/dL or higher) and increased cancer mortality in patients with stable coronary artery disease (CAD). This connection highlights the importance of hs-CRP as an early warning sign, prompting further investigation and proactive health management.

Why did the study focus on patients with stable CAD?

The study focused on patients with stable coronary artery disease (CAD) because they often experience chronic inflammation. This research analyzed data from 2,867 patients with stable CAD who underwent percutaneous coronary intervention (PCI). The findings showed that individuals with elevated hs-CRP levels had a higher risk of cancer death. Specifically, elevated hs-CRP was linked to increased deaths from gastrointestinal and lung cancers. This group was chosen because CAD patients may already have underlying health issues, and inflammation plays a role in their condition.

How can hs-CRP testing benefit individuals?

The study's findings suggest that hs-CRP measurement could be a valuable tool for identifying individuals at a higher risk of cancer death. Elevated hs-CRP levels do not directly diagnose cancer, but they can act as a warning sign. This early identification can lead to more proactive screening, potentially including further diagnostic tests like imaging or biopsies, and the implementation of preventative strategies, such as lifestyle modifications or targeted medical interventions. This will improve overall health outcomes.

What does this research mean for my health if I have CAD?

If you have stable CAD, understanding your hs-CRP levels is important. Elevated hs-CRP levels, at or above 0.10 mg/dL, may indicate a higher risk of cancer mortality. The study highlighted the link between inflammation and overall health, especially for individuals with cardiovascular conditions. You should discuss your hs-CRP results with your doctor and consider the need for more frequent cancer screenings and adopting a healthier lifestyle. The findings emphasize the importance of understanding your body and taking control of your health with your physician.