Symbolic illustration of breast cancer ribbon and stomach, representing the intersection of lobular breast cancer and gastric cancer risk.

Gastric Cancer Risk: What Women with Breast Cancer Need to Know

Samir D’Costa in Health & Wellness August 2025 • 4 min read.

"A deeper look into secondary gastric cancer following breast cancer diagnosis, metastatic awareness, and familial syndromes."

A recent study has sparked important discussions in the medical community regarding the potential link between lobular breast cancer and an increased risk of gastric cancer. While the initial research aimed to explore the possibility of gastric cancer occurring more frequently in women with invasive lobular breast cancer, the findings have opened the door to a broader conversation about the complexities of cancer diagnosis and the importance of vigilance.

This article delves into the nuances of this potential association, addressing concerns raised about misdiagnosis and highlighting the need for continued research. It's important for women, especially those with a history of lobular breast cancer, to understand the potential risks and advocate for thorough medical evaluations.

We'll explore the differences between secondary gastric cancer and metastatic breast cancer, discuss the limitations of current data, and consider the possibility of underlying genetic factors that may contribute to this increased risk. This information is designed to empower you to have informed conversations with your healthcare providers and make proactive decisions about your health.

Secondary vs. Metastatic: Understanding the Difference in Gastric Cancer and Lobular Breast Cancer

Symbolic illustration of breast cancer ribbon and stomach, representing the intersection of lobular breast cancer and gastric cancer risk.

One of the key points of discussion surrounding this research is the distinction between secondary gastric cancer and metastatic breast cancer. Metastatic breast cancer occurs when breast cancer cells spread to other parts of the body, including the stomach. Secondary gastric cancer, on the other hand, is a new, independent cancer that originates in the stomach.

Distinguishing between these two is crucial for appropriate treatment and management. While both can present similar symptoms, their origins and genetic makeup are different. Here’s what you need to know:

Metastatic Breast Cancer: Breast cancer cells spreading to the stomach.
Secondary Gastric Cancer: A new, independent cancer originating in the stomach.
Diagnosis Challenges: The ability of metastases to mimic primary cancer can be difficult.

While some argue that the increased incidence of gastric cancer in women with lobular breast cancer could be due to misdiagnosed metastatic cases, the researchers suggest that this is unlikely to be the sole explanation. Their analysis, using data from the SEER database, aims to minimize such errors by focusing on primary cancer diagnoses.

What This Means for You: Taking a Proactive Approach

While research continues to explore the potential link between lobular breast cancer and gastric cancer, it's important to stay informed and proactive about your health. If you have a history of lobular breast cancer, discuss your concerns with your doctor and ask about appropriate screening and monitoring strategies. Being aware of potential risks and advocating for thorough evaluations can help ensure early detection and optimal outcomes.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1016/j.breast.2017.07.011, Alternate LINK

Title: Re: Secondary Gastric Cancer Following A Breast Cancer Diagnosis; Beware Of Metastatic Breast Cancer

Subject: General Medicine

Journal: The Breast

Publisher: Elsevier BV

Authors: Alyson L. Mahar, Daniel J. Kagedan, Julie Hallet, Natalie G. Coburn

Published: 2017-10-01

Everything You Need To Know

What is the crucial difference between metastatic breast cancer and secondary gastric cancer when considering gastric cancer in women previously diagnosed with lobular breast cancer?

The key difference lies in their origin. Metastatic breast cancer to the stomach means breast cancer cells have spread to the stomach. Secondary gastric cancer, however, is a new, independent cancer that originates in the stomach lining itself. Distinguishing between metastatic breast cancer and secondary gastric cancer is critical because they require different treatment approaches. Genetic analysis and thorough pathological examination are essential to accurately determine the origin of the cancer.

How does the SEER database contribute to understanding the potential link between lobular breast cancer and gastric cancer?

The SEER database (Surveillance, Epidemiology, and End Results) is a comprehensive source of cancer statistics in the United States. Researchers use SEER to analyze cancer incidence and survival rates. By using SEER data, scientists aim to minimize errors and focus on primary cancer diagnoses. This helps in understanding the true incidence of secondary gastric cancer in women with lobular breast cancer, rather than misclassifying metastatic breast cancer as a new gastric cancer.

What proactive steps should women with a history of lobular breast cancer take regarding the potential risk of developing gastric cancer?

If you have a history of lobular breast cancer, it is crucial to have open discussions with your doctor about the potential risk, although still being researched, of developing secondary gastric cancer. You may need to inquire about appropriate screening and monitoring strategies. Although specific screening guidelines may not yet be established, proactively raising awareness and advocating for thorough evaluations can aid in early detection and improve outcomes.

Are there possible genetic or familial links that could explain the correlation between lobular breast cancer and an increased risk of secondary gastric cancer?

While research suggests a potential link between lobular breast cancer and an increased risk of secondary gastric cancer, the underlying mechanisms are still being investigated. One area of exploration is the possibility of shared genetic factors that predispose individuals to both cancers. Further research into familial syndromes and genetic mutations is needed to fully understand the genetic connection between these two types of cancer.

Does the increased risk of gastric cancer apply to all types of breast cancer, or is it specific to invasive lobular breast cancer?

The study primarily focuses on the potential increased risk of secondary gastric cancer in women with a history of invasive lobular breast cancer. Other subtypes of breast cancer were not explicitly addressed. Further research is needed to determine if similar associations exist between other breast cancer subtypes and gastric cancer risk. The unique characteristics of invasive lobular breast cancer may play a role in this potential association, warranting further investigation into the specific mechanisms involved.