Labrador Retriever running with DNA helix overlay, symbolizing genetic factors in canine health.

Decoding CCLR in Labrador Retrievers: Is There a Link to EIC, Sex, or Sterilization?

Samir D’Costa in Health & Wellness December 2025 • 4 min read.

"New research sheds light on the complex factors influencing cranial cruciate ligament rupture (CCLR) in Labradors, exploring connections with exercise-induced collapse (EIC), sex, and sterilization practices."

Labrador Retrievers, beloved for their energy and loyalty, are unfortunately prone to certain health issues. Among these, cranial cruciate ligament rupture (CCLR), analogous to an ACL tear in humans, and exercise-induced collapse (EIC), a concerning condition triggered by strenuous activity, are particularly common. Understanding the factors that contribute to these conditions is crucial for ensuring the health and well-being of these cherished companions.

A groundbreaking study published in Canine Genetics and Epidemiology has delved into the complex interplay of genetics, sex, and sterilization status in Labrador Retrievers affected by CCLR. Researchers investigated a cohort of 313 Labradors, carefully categorizing them based on their CCLR status and subsequently conducting genetic testing for EIC. In addition, they meticulously collected epidemiological data, including sex, sterilization status, and age at sterilization, to paint a comprehensive picture of the factors at play.

This article breaks down the key findings of this research, offering Labrador owners and breeders a clear understanding of the potential links between CCLR, EIC, sex, and sterilization practices. By exploring these connections, we aim to empower you with the knowledge to make informed decisions about your dog's health and care, ultimately contributing to a happier, healthier life for your furry friend.

Unpacking the EIC and CCLR Connection: What Does the Research Say?

Labrador Retriever running with DNA helix overlay, symbolizing genetic factors in canine health.

The study's initial focus was on determining whether a direct association exists between CCLR and EIC susceptibility. EIC, caused by a mutation in the DNM1 gene, can lead to episodes of weakness and collapse after intense exercise. Researchers hypothesized that the stress placed on the joints during these episodes, or potential neurological impacts from the DNM1 mutation, might increase the risk of CCLR.

However, the results revealed no statistically significant association between CCLR status and EIC susceptibility. While a slightly higher percentage of CCLR cases had the EIC-susceptible genotype (4.6%) compared to CCLR-normal dogs (2.2%), this difference was not significant enough to establish a direct link. This suggests that while both conditions are prevalent in Labradors, they may often occur independently.

No Direct Link: The study didn't find solid proof that EIC directly causes more CCLR in Labradors.
Independent Issues: Both EIC and CCLR are common, but they seem to show up separately in many dogs.
Other Factors: More research is needed to understand other possible connections and risk factors.

It's important to note that the study acknowledged its limitations, including a relatively small sample size, which may have limited its ability to detect subtle associations. Despite this, the findings provide valuable insights, suggesting that CCLR and EIC are not necessarily intertwined in Labrador Retrievers. This doesn't eliminate the possibility of a connection, but it emphasizes the need to consider other contributing factors.

What Does It All Mean for Labrador Owners?

This study offers valuable insights for Labrador owners, emphasizing the complex nature of CCLR and the importance of considering various factors in your dog's health. While a direct link between EIC and CCLR wasn't established, the research highlighted potential connections between sex, sterilization status, and CCLR risk, particularly in females. Understanding these nuances can empower you to make informed decisions about your Labrador's care, working closely with your veterinarian to ensure their well-being.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1186/s40575-017-0041-9, Alternate LINK

Title: Dnm1 Mutation Status, Sex, And Sterilization Status Of A Cohort Of Labrador Retrievers With And Without Cranial Cruciate Ligament Rupture

Subject: General Medicine

Journal: Canine Genetics and Epidemiology

Publisher: Springer Science and Business Media LLC

Authors: Kari J Ekenstedt, Katie M Minor, Aaron K Rendahl, Michael G Conzemius

Published: 2017-02-02

Everything You Need To Know

What is Cranial Cruciate Ligament Rupture (CCLR), and why is understanding it important for Labrador Retriever owners?

Cranial Cruciate Ligament Rupture, or CCLR, is similar to an ACL tear in humans and is a common injury in Labrador Retrievers. The study sought to understand if Exercise-Induced Collapse (EIC), sex, or sterilization practices contributed to CCLR risk. While the study did not establish a direct link between EIC and CCLR, it underscores the importance of further research into the multifactorial causes of CCLR, beyond just EIC susceptibility. Understanding CCLR is vital for Labrador owners, as it enables them to take proactive measures in preventing injury and ensuring appropriate care.

What is Exercise-Induced Collapse (EIC) in Labrador Retrievers, and how does it relate to this study?

Exercise-Induced Collapse, or EIC, is a condition in Labrador Retrievers caused by a mutation in the DNM1 gene, leading to weakness and collapse after strenuous exercise. While the study examined EIC's role in CCLR, no statistically significant link was found, suggesting both conditions often occur independently. Knowing about EIC is essential for owners to manage their dog's activity levels, preventing potential episodes and ensuring their Labrador's safety. Genetic testing can determine if a dog is susceptible to EIC, further informing exercise management strategies.

Did the research definitively prove that Exercise-Induced Collapse (EIC) causes Cranial Cruciate Ligament Rupture (CCLR) in Labrador Retrievers?

The research did not find a direct, statistically significant relationship between Exercise-Induced Collapse (EIC) and Cranial Cruciate Ligament Rupture (CCLR). This means that while both conditions are prevalent in Labrador Retrievers, having EIC does not necessarily increase the likelihood of CCLR, and vice versa. This suggests that other factors, beyond the DNM1 gene mutation responsible for EIC, may play a more significant role in CCLR development. However, it is important to remember that the sample size was relatively small, so there is still a possibility of a link.

If there is no direct link between Exercise-Induced Collapse (EIC) and Cranial Cruciate Ligament Rupture (CCLR), what are the key takeaways for Labrador owners regarding CCLR risk?

The study highlights the importance of considering multiple factors when assessing a Labrador Retriever's risk for Cranial Cruciate Ligament Rupture (CCLR). While the study didn't prove Exercise-Induced Collapse (EIC) directly causes CCLR, this research opens doors to explore other potential genetic and environmental components. Owners should be aware of their dog’s predisposition to EIC but should be more concerned about other contributors. Sex, age, and sterilization status were mentioned in the study, but the research suggested further exploration.

How does the lack of a direct link between Exercise-Induced Collapse (EIC) and Cranial Cruciate Ligament Rupture (CCLR) influence breeding and preventative care strategies for Labrador Retrievers?

The study, while not establishing a direct link between Exercise-Induced Collapse (EIC) and Cranial Cruciate Ligament Rupture (CCLR), helps breeders and owners understand that these health issues may require separate management strategies. Breeders can focus on screening for the DNM1 gene to reduce EIC susceptibility within their breeding lines, while owners can implement preventive measures for CCLR by managing their dog's weight, exercise, and overall joint health. More research is needed to give a full understanding.