Leptadenia hastata and sperm cells illustration

Can Natural Remedies Affect Male Fertility? The Truth About Leptadenia Hastata

Theo Raines in Health & Wellness December 2025 • 4 min read.

"A new study explores the impact of a traditional African plant on sperm health and testicular function in rats, revealing potential risks and benefits."

For centuries, people across the globe have turned to natural remedies derived from plants to address various health concerns. Among these, the quest for boosting or regulating fertility has been a prominent area of interest. In Africa, traditional medicine utilizes a wide array of plants believed to possess fertility-enhancing or controlling properties.

One such plant, Leptadenia hastata, has garnered attention for its potential effects on the reproductive system. Known by various local names across Nigeria, including 'Njara' in Kanuri and 'Yadiya' in Hausa, this perennial plant has been traditionally used for different medicinal purposes. However, questions remain regarding its true impact on fertility, particularly male reproductive health.

A recent study delved into this very question, seeking to understand how Leptadenia hastata affects sperm quality and testicular health. By examining the effects of aqueous leaf extracts of the plant on rats, researchers aimed to shed light on its potential benefits and risks, offering valuable insights for those curious about natural fertility solutions.

Does Leptadenia Hastata Impact Sperm Health?

Leptadenia hastata and sperm cells illustration

Researchers at the University of Maiduguri, Nigeria, conducted a study to determine how prolonged use of Leptadenia hastata leaf extract affects male fertility. They administered different doses of the extract to Wistar rats over 28 days, monitoring changes in sperm concentration, sperm motility, testicular weight, and the structure of the testes.

The study revealed some interesting findings:

Sperm Concentration and Motility: At the highest dose (800 mg/kg), the extract caused a significant reduction in sperm concentration and motility.
Testicular Weight: The group receiving the highest dose also experienced a reduction in testicular weight.
Histopathology: Microscopic examination showed depletion of sperm cells in the testes and epididymis of rats given the 800 mg/kg dose.
No Significant Change at Lower Doses: The lower doses tested did not cause significant changes in sperm concentration, motility, or testicular weight.

These results suggest that while low dosages of Leptadenia hastata may not cause significant harm, higher dosages could negatively impact sperm production, sperm movement and testicular health.

The Bottom Line: Proceed with Caution

The study highlights the potential risks associated with using high doses of Leptadenia hastata. While natural remedies may seem appealing, it's crucial to recognize that they can have potent biological effects, especially when taken in large quantities or over extended periods.

If you're considering using Leptadenia hastata or any other herbal remedy to address fertility concerns, it's essential to consult with a qualified healthcare professional. They can provide personalized guidance based on your individual health status and help you weigh the potential benefits against the risks.

Ultimately, this research serves as a reminder that natural doesn't always equal safe. Understanding the science behind traditional remedies is key to making informed decisions about your health and well-being.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.5897/jmpr2018.6568, Alternate LINK

Title: Effect Of Aqueous Leaf Extracts Of Leptadenia Hastata Pers (Decne) On Spermiogram And Testicular Histology In Albino Rats (Wistar Strain)

Subject: Complementary and alternative medicine

Journal: Journal of Medicinal Plants Research

Publisher: Academic Journals

Authors: Adam Maina Victoria, Damudu Peter Innocent, Yahi Dauda, Kyari Sandabe Umar, Onyeamaechi Egwu Godwin

Published: 2018-04-11

Everything You Need To Know

What is Leptadenia hastata?

Leptadenia hastata is a plant utilized in traditional African medicine, particularly in Nigeria where it's known by names like 'Njara' and 'Yadiya'. It has been traditionally used for various medicinal purposes, and has gained attention for its potential effects on the reproductive system. A study conducted by researchers examined its impact on sperm health and testicular function.

What were the key findings regarding Leptadenia hastata's impact on male fertility?

The recent study observed that high doses of Leptadenia hastata leaf extract (800 mg/kg) administered to rats over 28 days significantly reduced sperm concentration and motility. The same dose also led to a decrease in testicular weight and depletion of sperm cells in the testes and epididymis. These findings suggest that high doses might negatively affect sperm production and testicular health.

What are the implications of using Leptadenia hastata based on this study?

The implications of these findings are significant. They suggest that while some natural remedies like Leptadenia hastata might be used in traditional medicine, the dosage is crucial. High doses could pose risks to male fertility by impairing sperm production and motility. The study highlights the need for caution and further research to understand the plant's effects fully, ensuring safe usage.

How was the study conducted to investigate the effects of Leptadenia hastata?

The study tested different doses of Leptadenia hastata leaf extract on Wistar rats, monitoring changes in sperm concentration, sperm motility, testicular weight, and the structure of the testes. The researchers found that while lower doses did not cause significant changes, the highest dose (800 mg/kg) showed detrimental effects. The study design allowed researchers to assess the dose-dependent effects of the extract on male reproductive health.

What is the primary takeaway from the study on Leptadenia hastata?

The bottom line from the study is that caution is advised when using high doses of Leptadenia hastata. While natural remedies may seem harmless, they can have strong biological effects, particularly when taken in large amounts or over a prolonged period. The study's results emphasize the importance of understanding both the potential benefits and risks before using natural remedies, especially those related to fertility.