Sperm cells moving towards a hopeful destination, symbolizing improved fertility.

Boost Your Fertility? How Daily Tadalafil Could Be a Game-Changer

Lena Voss in Health & Wellness December 2025 • 4 min read.

"Research suggests that a daily dose of Tadalafil, commonly used for erectile dysfunction, may improve sperm quality in men."

Erectile dysfunction (ED) is a common concern for men, and Tadalafil, a phosphodiesterase 5 (PDE5) inhibitor, is a well-known treatment option. But Tadalafil's potential benefits may extend beyond just treating ED. Emerging research suggests it could also play a role in improving sperm quality.

Sperm motility, concentration, and overall semen volume are critical factors for male fertility. Many couples face challenges when trying to conceive, and male infertility contributes significantly to these difficulties. Finding ways to safely and effectively enhance sperm parameters is an ongoing area of research.

A recent study investigated the effects of daily Tadalafil administration on sperm quality in a group of men with psychogenic ED. The findings revealed promising improvements in several key sperm characteristics. This article explores the study's results, what they might mean for male fertility, and the potential mechanisms behind these improvements.

Tadalafil: More Than Just an ED Drug?

Sperm cells moving towards a hopeful destination, symbolizing improved fertility.

The study, published in Archivio Italiano di Urologia e Andrologia, enrolled 27 men aged 19 to 35 experiencing psychogenic ED. Psychogenic ED refers to ED caused by psychological factors rather than physical ones. Importantly, the men were unaware of their fertility status before participating.

The participants received 5mg of Tadalafil daily for 12 weeks. Before and after the treatment period, researchers analyzed several key parameters of their semen, including:

Semen volume
Sperm concentration
Sperm motility (both total and progressive)
Percentage of normal sperm

The results showed statistically significant improvements in sperm motility, the percentage of healthy sperm, and semen volume after the 3-month Tadalafil treatment. Specifically, the men experienced an average increase in total sperm count, fast-moving sperm, and the percentage of healthy sperm. The average semen volume also saw a positive change.

What Does This Mean for Your Fertility Journey?

The study's findings suggest that daily Tadalafil administration could potentially improve sperm quality in some men, particularly those with psychogenic ED. However, it's important to note that this was a relatively small study, and further research is needed to confirm these results and determine the long-term effects.

The researchers propose that Tadalafil's positive effects on sperm quality may be related to its impact on nitric oxide (NO) levels in the body. NO plays a crucial role in various physiological processes, including vasodilation (the widening of blood vessels) and sperm function. Tadalafil may enhance NO-mediated mechanisms in the prostate and testicular tissue, leading to improved sperm production and motility.

If you and your partner are facing fertility challenges, it's essential to consult with a healthcare professional for a comprehensive evaluation. While Tadalafil may offer a potential avenue for improving sperm quality, it's not a guaranteed solution, and other factors could be contributing to infertility. A doctor can help determine the underlying causes and recommend the most appropriate treatment options for your specific situation.

About this Article -

This article was crafted using a human-AI hybrid and collaborative approach. AI assisted our team with initial drafting, research insights, identifying key questions, and image generation. Our human editors guided topic selection, defined the angle, structured the content, ensured factual accuracy and relevance, refined the tone, and conducted thorough editing to deliver helpful, high-quality information.See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.4081/aiua.2015.3.210, Alternate LINK

Title: Once-A-Day Tadalafil Administration Improves The Spermogram Parameters In Fertile Patients

Subject: Urology

Journal: Archivio Italiano di Urologia e Andrologia

Publisher: PAGEPress Publications

Authors: Antonio Corvasce, Giuseppe Albino, Teresa Leonetti, Agnese Filomena Buonomo, Ettore Cirillo Marucco

Published: 2015-09-30

Everything You Need To Know

Could taking Tadalafil daily improve sperm quality?

The study indicates that daily Tadalafil intake over 12 weeks can lead to improvements in sperm motility, semen volume, and the percentage of healthy sperm in men experiencing psychogenic ED. Specifically, participants saw an increase in total sperm count and fast-moving sperm.

Besides erectile dysfunction, what other benefits might Tadalafil offer?

Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor primarily used to treat erectile dysfunction (ED). The study suggests Tadalafil may enhance male fertility by improving sperm parameters such as motility and concentration. While originally used for ED, research indicates it could positively influence sperm health.

What exactly is psychogenic erectile dysfunction, and why was it important in this study?

Psychogenic ED refers to erectile dysfunction caused by psychological factors rather than physical ones. The study focused on men with psychogenic ED to assess the impact of Tadalafil on their sperm quality. It is important to distinguish it from ED caused by physical factors when considering treatment options.

What sperm characteristics are most important for fertility, and how did Tadalafil affect them?

Key indicators like sperm motility, concentration, and overall semen volume are crucial for male fertility. The study measured these parameters before and after Tadalafil treatment. Improvements in these areas suggest a potential pathway for enhancing fertility, particularly for couples facing conception challenges due to male infertility factors. However, this was a small study and more studies are needed to confirm the results.

Can you describe the design and key elements of the Tadalafil study?

The study, published in *Archivio Italiano di Urologia e Andrologia*, involved 27 men aged 19 to 35 with psychogenic ED who took 5mg of Tadalafil daily for 12 weeks. Researchers analyzed their semen before and after the treatment, focusing on semen volume, sperm concentration, sperm motility, and percentage of normal sperm to determine the impact of Tadalafil. It's worth noting that the men were unaware of their fertility status prior to the study.