Pulsating skin lesions from insect bites.

Blinking Skin? Unmasking the Mystery of Pulsatile Papules and Plaques

Avery Sinclair in Health & Wellness June 2025 • 4 min read.

"Discover a rare dermatological puzzle: How insect bites can lead to pulsating skin lesions and what it reveals about your health."

Have you ever heard of skin that blinks? It sounds like something out of a science fiction movie, but it's a real, albeit rare, dermatological phenomenon known as Quincke's sign. Typically associated with cardiovascular conditions, this unusual sign can manifest as alternating blanching and flushing of the skin in rhythm with arterial pulsation.

In a fascinating case study, doctors encountered a 5-year-old boy whose skin appeared to 'pulsate' following insect bites. This bizarre presentation led to a deeper investigation into the connection between seemingly harmless bug bites and this peculiar vascular response.

This article delves into the details of this unique case, exploring the potential mechanisms behind pulsating skin lesions and what it could mean for your understanding of dermatological health. We'll break down the medical jargon and shed light on this unusual condition, offering insights for both the curious and those seeking answers.

The Case of the Pulsating Papules: When Insect Bites Cause a Bizarre Reaction

Pulsating skin lesions from insect bites.

In a recent case report, a 5-year-old boy presented with itchy papules and plaques that initially appeared on his right leg before spreading to his limbs, buttocks, and wrists. These lesions emerged at the sites of insect bites he sustained after attending an outdoor music festival. What made this case particularly intriguing was the pulsating nature of some of the lesions, which began two days after they first appeared.

Physical examination revealed scattered erythematous, urticated papules and plaques, primarily located on the patient's legs, buttocks, and wrists. Several of these lesions exhibited a distinct pulsatility, characterized by alternating erythema and blanching synchronized with the patient's pulse. This pulsatility was more noticeable when the patient was lying down and diminished when he stood up. Aside from these unusual skin findings, the remainder of the physical and cardiovascular examinations were normal.

Medical History: The patient had a history of molluscum contagiosum and a skull fracture.
Histological Findings: A punch biopsy from the left knee revealed spongiotic dermatitis with pustules and inflammation featuring eosinophils, consistent with an insect bite. Direct immunofluorescence was negative.
Diagnostic Tests: Full blood count, renal and liver function tests were unremarkable, and testing for antinuclear antibody was negative. A Doppler ultrasonography scan (USS) of the lesions showed increased echogenicity in the subcutaneous soft tissues but normal blood flow.

Based on these findings, a diagnosis of Quincke's sign arising within multiple insect bite lesions was made. The patient was treated with clobetasone butyrate 0.05% ointment and emollient cream. Over several days, the pulsatility gradually decreased, and the lesions resolved completely without scarring after four weeks.

What Does This Mean for You? Understanding the Implications of Blinking Skin

This case highlights the importance of recognizing unusual dermatological manifestations, even in seemingly straightforward cases like insect bites. While Quincke's sign is typically associated with cardiovascular conditions, this case demonstrates that it can also occur in healthy individuals as a response to insect bites. If you notice any unusual pulsating lesions on your skin, especially after insect bites, it's essential to seek medical evaluation to rule out any underlying conditions and receive appropriate treatment.

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Everything You Need To Know

What exactly is Quincke's sign, and what is it usually associated with?

Quincke's sign is a rare phenomenon characterized by the alternating blanching and flushing of the skin in rhythm with arterial pulsation. Typically, it's associated with cardiovascular conditions, indicating potential heart-related issues. However, as demonstrated, it can also manifest in response to other stimuli, such as insect bites, showcasing the complexity of dermatological responses and the body's reaction to localized trauma or inflammation.

Why is it unusual to see Quincke's sign in relation to insect bites?

The appearance of Quincke's sign, or pulsating skin lesions, after insect bites is significant because it highlights an unusual dermatological manifestation that is not commonly associated with insect bites. Typically, Quincke's sign is linked to cardiovascular conditions, not bug bites. This demonstrates that various triggers can cause it. This case broadens the understanding of potential causes and emphasizes the importance of recognizing atypical symptoms, even in seemingly benign conditions like insect bites.

What are the patient's prior medical conditions, and how do they relate to the pulsating skin lesions?

In the presented case, the boy had a history of molluscum contagiosum and a skull fracture. Molluscum contagiosum is a viral skin infection that causes raised, pearly bumps. A skull fracture, while seemingly unrelated to the skin lesions, represents a previous trauma. These historical details, along with the histological findings indicating spongiotic dermatitis with pustules and eosinophils (consistent with an insect bite reaction), contribute to a comprehensive understanding of the patient's medical background and potential predisposing factors to the unusual reaction.

What did the various diagnostic tests reveal about the cause of the patient's condition?

The diagnostic tests, including a full blood count, renal and liver function tests, and testing for antinuclear antibodies, were all unremarkable, meaning they showed no significant abnormalities. Doppler ultrasonography (USS) of the lesions revealed increased echogenicity in the subcutaneous soft tissues but normal blood flow. The normal blood flow indicated that the pulsatility was not due to major vascular abnormalities. These results helped to rule out other underlying systemic conditions, pointing toward a localized reaction to the insect bites as the primary cause of the Quincke's sign.

What treatments were used, and how effective were they in resolving the pulsating skin lesions?

The patient was treated with clobetasone butyrate 0.05% ointment and emollient cream. Clobetasone butyrate is a topical corticosteroid used to reduce inflammation and itching, while emollient cream is a moisturizer used to soothe and hydrate the skin. This treatment approach aimed to alleviate the symptoms (inflammation and discomfort) and support skin healing. The pulsatility gradually decreased, and the lesions resolved completely without scarring after four weeks, indicating the treatment was effective in managing the localized reaction and preventing long-term complications.