Abstract illustration representing acute flaccid myelitis research and the search for a cure.

Acute Flaccid Myelitis: What You Need to Know About This Mysterious Illness

"A CDC task force is investigating the rise of acute flaccid myelitis (AFM) cases in children, a condition causing muscle weakness and paralysis. Understand the potential causes, symptoms, and what's being done to combat this concerning trend."


In recent years, a concerning trend has emerged in the United States: an increase in cases of acute flaccid myelitis (AFM), a rare but serious condition primarily affecting children. AFM impacts the spinal cord, leading to muscle weakness and, in some cases, paralysis. The Centers for Disease Control and Prevention (CDC) is taking action, launching a task force to investigate the causes, treatments, and potential prevention strategies for this mysterious illness.

Since 2014, the USA has witnessed a troubling rise in confirmed AFM cases, a condition for which there is currently no cure or vaccine. As of this year, 106 confirmed cases have emerged across 29 states, predominantly affecting children under 18. This increase has prompted concern among medical professionals and families alike, highlighting the urgent need for research and understanding.

Recognizing the gravity of the situation, the CDC established the AFM task force, comprised of experts from diverse scientific, medical, and public health disciplines. Scheduled to deliver its initial report on December 6, the task force aims to consolidate expertise and insights to guide future research and public health interventions. Robert R Redfield, director of the CDC, has emphasized the agency's commitment to addressing this serious medical condition, reaffirming support for affected patients and their families.

Unraveling the Mystery: What Causes Acute Flaccid Myelitis?

Abstract illustration representing acute flaccid myelitis research and the search for a cure.

One of the biggest challenges in tackling AFM is identifying its cause. While the exact triggers remain unknown, research points to a potential culprit: enteroviruses. These common viruses, which typically cause mild illnesses like colds, have been increasingly linked to AFM cases. Specifically, enterovirus D68 (EV-D68) has emerged as a leading suspect.

Clinicians have noted a correlation between EV-D68 outbreaks and increases in AFM cases. Kevin Messacar, an infectious disease physician, initiated a search for EV-D68 following a 2014 outbreak, discovering its presence in nasal swabs from patients exhibiting cold-like symptoms. Additionally, other enteroviruses, such as EV-A71, have been implicated, suggesting a complex interplay of viral factors.
  • Enteroviruses: A group of viruses, including EV-D68 and EV-A71, that may trigger AFM.
  • EV-D68: An enterovirus found in some AFM cases, sparking research into its role.
  • Seasonal Patterns: Enterovirus outbreaks often peak in late summer and autumn.
Despite the growing evidence linking enteroviruses to AFM, the CDC remains cautious, emphasizing that the cause of AFM remains unknown. Further research is needed to definitively establish the causal relationship and understand why some enterovirus infections lead to AFM while others do not. Factors such as individual susceptibility, viral strain variations, and environmental influences may all play a role.

Hope for the Future: Research, Surveillance, and Prevention

While AFM remains a complex and challenging condition, ongoing research and surveillance efforts offer hope for improved understanding, treatment, and prevention. The CDC's task force plays a crucial role in coordinating research, gathering data, and developing strategies to combat AFM. Active surveillance of enteroviruses, particularly EV-D68, is essential for early detection and timely intervention. As Kevin Messacar aptly stated, "We were able to detect early when the pathogen was circulating."

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