Unlocking Nature's Pharmacy: The Healing Power of Ficus Krishnae

Ficus krishnae, belonging to the Moraceae family and known for its distinctive pocket-like folds at the base of its leaves, has been traditionally utilized to address various health conditions like ulcers, fever, inflammations, and even leprosy. Recent research underscores the antimicrobial properties of the stem bark extract, further highlighting the plant's phytoactive compounds. Gas Chromatography-Mass Spectrometry (GC-MS) analysis of the petroleum ether extract of Ficus krishnae stem bark has identified twelve bioactive compounds, each contributing to its potential therapeutic benefits. These include compounds like 9,12,15-Octadecatrienoic acid, Mellein, and Lupeol, known for their anti-inflammatory, antioxidant, and antimicrobial properties.

Gas Chromatography-Mass Spectrometry (GC-MS) is utilized to identify the secondary metabolites present in Ficus krishnae. The GC-MS method involves using gas chromatography to separate the compounds based on their retention time (RT), followed by molecular analysis using mass spectrometry. The mass spectrometer then analyzes the eluted compounds to determine their nature and structure. Each compound's mass spectrum serves as a unique fingerprint, which helps in identifying compounds via library searches. This process helps reveal the potential bioactive compounds within Ficus krishnae, like Betulin and Cholestane-3,6,7-triol.

The GC-MS analysis of Ficus krishnae stem bark extract identified twelve bioactive compounds within the petroleum ether extract. These include 9,12,15-Octadecatrienoic acid, known for its anti-inflammatory properties; Mellein, which may be useful in treating respiratory issues; Betulin, a triterpene with anti-inflammatory and antibacterial effects; Lupeol, with antiprotozoal, antimicrobial, anti-inflammatory, antitumor, and chemopreventive properties; Cholestane-3,6,7-triol, which exhibits antibacterial activity; and Bolasterone, an anabolic steroid potentially useful for restoring muscle strength and enhancing heart function. Other identified compounds include Oleic Acid, 3-(octadecyloxy)propyl ester; Phytol; n-Hexadecanoic Acid; 1(+) Ascorbic Acid 2,6-dihexadecanoate; Cyclopentasiloxane, decamethyl; and Geranyl Isovalerate. These compounds contribute to the plant's diverse therapeutic potential.

9,12,15-Octadecatrienoic acid is an essential fatty acid known for its anti-inflammatory properties. Mellein is a phenol derivative potentially useful in treating respiratory issues like asthma and tuberculosis. Betulin is a triterpene with anti-inflammatory and antibacterial effects. Lupeol is another triterpene that possesses antiprotozoal, antimicrobial, anti-inflammatory, antitumor, and chemopreventive properties. Cholestane-3,6,7-triol is a steroid showing antibacterial activity. Bolasterone is an anabolic steroid that restores muscle strength and enhances heart function. These bioactive compounds contribute to the overall therapeutic potential of Ficus krishnae. However, more research is required to fully understand the functions and side effects when used to treat ailments.

Future research on Ficus krishnae should focus on exploring the specific mechanisms and applications of its bioactive compounds, such as 9,12,15-Octadecatrienoic acid and Lupeol, to pave the way for new natural therapies. Detailed studies are needed to understand their effects on various ailments, optimize extraction methods, and assess potential side effects. Moreover, integrating this knowledge with traditional uses could refine phytopharmaceutical applications. Additional research should also explore synergistic effects among the identified compounds and investigate sustainable sourcing methods to ensure the plant's long-term availability for medicinal use.