Surreal illustration of a nurse struggling to sleep, symbolizing the connection between insomnia and heart health.

Sleepless Nights & Heart Troubles: Is Insomnia or Night Shift Work to Blame?

"New research disentangles the complex relationship between sleep disorders, shift work, and cardiovascular disease in nursing professionals, offering critical insights for healthcare workers and employers."


Cardiovascular diseases (CVDs) and poor sleep are known to be linked, but the impact of specific work schedules, like night shifts, has been less clear. Many studies look at CVD and work schedules separately, potentially missing crucial connections. New research investigates the combined effects of insomnia and night work on CVD risk among female nursing professionals, aiming to disentangle these complex relationships.

The study, published in the Brazilian Journal of Medical and Biological Research, involved 1307 female nurses from three public hospitals. Researchers analyzed the association between insomnia and self-reported physician diagnoses of CVD in both day and night workers. A key aspect was considering all sleep episodes, including both nocturnal and diurnal (daytime) sleep, particularly important for night workers who often sleep during the day.

By examining these factors together, the study aimed to determine whether CVD risk is more closely tied to night work itself or to the sleep disturbances that often accompany it. This distinction is critical for developing targeted interventions to protect the health of nursing professionals and potentially other shift workers.

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Insomnia’s Cardiovascular Impact

Insomnia is described by the American Heart Association as one of the most common sleep disorders, affecting the ability to fall asleep, stay asleep, or obtain good sleep. Its symptoms can include daytime sleepiness, low energy, and difficulties with concentration, focus, and memory. A 2026 Frontiers in Psychiatry article notes that insomnia remains underdiagnosed and undertreated in coronary heart disease care, where clinical attention has disproportionately focused on sleep-disordered breathing. The CDC’s National Center for Health Statistics provides official sleep-health statistics through its FastStats application.

Multimodal Sleep Care

The sources describe approaches that address sleep through more than one dimension, including sleep hygiene, behavioral modification, self-management, and cognitive behavioral therapy for insomnia (CBT-I). Research in adults with chronic heart failure has evaluated changes in sleep-health phenotypes after CBT-I or attention-based interventions rather than focusing on a single sleep characteristic. A systematic review reports a randomized study of 34 patients comparing general sleep education combined with web-based CBT-I against general sleep education alone followed by a wait-list treatment opportunity. However, the precise relationship between insomnia subtypes and subsequent heart-failure risk remains poorly understood.

Insomnia, Not Just Night Work, Increases CVD Risk

Surreal illustration of a nurse struggling to sleep, symbolizing the connection between insomnia and heart health.

The study revealed a significant association between insomnia and CVD, regardless of whether participants worked during the day or night. Among day workers, those with insomnia complaints had a 2.79 times greater chance of reporting a CVD diagnosis compared to those without sleep issues. Night workers reporting insomnia during both nocturnal and diurnal sleep periods showed a 3.07 times greater chance of CVD.

These findings suggest that insomnia, rather than night work alone, may be the primary driver of increased CVD risk in this population. This is a crucial distinction because it highlights the importance of addressing sleep quality and duration, regardless of work schedule. The research underscores that the consequences of disturbed sleep are important regardless of when those disturbances occur.

  • Day Workers: Insomnia complaints increased the odds of CVD by 2.79 times.
  • Night Workers: Insomnia during both night and day sleep increased the odds of CVD by 3.07 times.
  • Key takeaway: The likelihood of reporting CVD was similar for both day and night workers experiencing insomnia.
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Shift Work and Sleep Quality

A cross-sectional study of U.S. adults reported a positive association between evening or night work schedules and coronary heart disease or angina. That study also emphasized the role of sleep quality in the occurrence of coronary heart disease and angina among evening or night workers. A systematic review of healthcare shift workers found that night workers had significantly poorer sleep quality than day or evening workers, including shorter sleep duration, greater daytime dysfunction, and poorer overall sleep quality. Research on shift work disorder likewise compares night workers with and without the disorder and day and night workers with insomnia.

Separating Insomnia From Night Work

Evidence does not uniformly show that night work itself explains cardiovascular risk. In nursing professionals, the probability of self-reporting a physician diagnosis of cardiovascular disease was similar among day and night workers with insomnia, suggesting an association with insomnia rather than night work per se. Observational and Mendelian-randomization studies have found strong associations between insomnia and cardiovascular disease, but Mendelian-randomization findings on causality have been inconsistent. Meta-analytic evidence has nevertheless reported significant longitudinal associations between different insomnia symptoms and incident heart failure.

A Bidirectional Relationship

A 2026 synthesis reported that insomnia was associated with a 45% increase in cardiovascular disease risk across 15 cohort studies involving 2.1 million participants, while cardiovascular disease could in turn worsen sleep. Another review described insomnia as a consistent, dose-dependent cardiovascular risk factor but noted that trials have not shown that treating insomnia lowers cardiovascular risk. Circadian rhythms influence sleep-wake cycles as well as blood pressure, vascular tone, endothelial function, insulin sensitivity, and inflammation. These findings frame insomnia and cardiovascular disease as interconnected while leaving the benefits of treatment for cardiovascular prevention unresolved.

Several factors could explain the link between insomnia and CVD. Sleep deprivation can disrupt the body's natural rhythms, leading to increased blood pressure and heart rate. Inflammation, glucose metabolism disorders, and increased sympathetic nervous system activity are also potential contributing mechanisms. The research adjusted for various confounding variables, including psychosocial factors, further strengthening the argument that insomnia plays a direct role.

Protecting Your Heart: Prioritizing Sleep for All

This study provides valuable insights for nursing professionals and other shift workers concerned about their cardiovascular health. The key takeaway is that addressing insomnia and improving sleep quality should be a priority, regardless of when you work. Simple steps, such as optimizing sleep environment, regular sleeping routine or seeking help from a sleep specialist may help in managing work-related sleep disturbances.

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Digital and Home-Based Care

The SLEEP 2026 Annual Meeting in Baltimore, held June 14–17, featured new research on insomnia’s cardiovascular risk, shift work, digital CBT-I, and home sleep diagnostics. The meeting’s clinical summary indicates that these areas are emerging fronts in research and care. Digital CBT-I may broaden access to behavioral treatment, while home sleep diagnostics could support assessment outside traditional clinical settings. The available source identifies these developments but does not establish whether they reduce cardiovascular events.

Persistent Symptoms Matter

Large prospective cohort studies and meta-analyses have consistently associated insomnia symptoms and clinically diagnosed insomnia with higher risks of hypertension, myocardial infarction, stroke, heart failure, and cardiovascular mortality. The reported associations are stronger among people with short sleep duration or persistent insomnia. Recent research also links chronic insomnia symptoms with an elevated risk of incident heart failure and suggests a dose-response pattern based on the number and severity of symptoms. These findings highlight why persistent sleep problems can have consequences beyond nighttime discomfort.

For employers, these findings highlight the need to implement strategies that support the sleep health of their employees, especially those working non-traditional hours. This could include offering sleep health education, providing resources for managing insomnia, and creating work environments that promote rest and recovery.

Ultimately, recognizing sleep disturbance as a public health concern and prioritizing sleep for everyone, not only benefits individual health but also enhances workforce well-being and productivity.

The weight of this cross-sectional evidence

Observational study (level 4 of 8)

The analysis drew on female nursing professionals, so its findings describe this group rather than all workers or the wider population.[1]

How insomnia complaints differed across sleep periods

  • 35%; 13% of night workersAmong night workers, 35% reported insomnia complaints during daytime sleep; 13% reported complaints during both daytime and nighttime sleep.[2]

What keeps the nursing study from settling the question

  • Even with adjustments for potential confounders, unmeasured or residual influences could remain.[2]

The nursing study at a glance

Study designObservational study[1]
PopulationFemale nursing professionals who worked days without previous night shifts or exclusively at night[1]
Sample size1307[1]
Setting3 public hospitals[1]
ComparisonDay workers with no previous night-shift experience compared with workers who worked exclusively at night[1]
Main outcomeSelf-reported physician diagnosis of cardiovascular diseases[1]
Effect sizeAmong day workers, nocturnal insomnia complaints: OR 2.79; among night workers, diurnal and nocturnal insomnia complaints: OR 3.07[1]
Confidence intervalDay workers: 1.01-6.71; night workers: 1.30-7.24[1]
Times cited25[1]

Questions left open by the study

  • Would repeated measurements over time clarify whether insomnia complaints precede reported CVD diagnoses or follow them?[1] [2]
  • Would results differ across more varied work schedules and patterns of nights worked?[1]
  • How much might the healthy-worker effect have influenced the observed association?[1]

About this Article -

Written with AI assistance from published research, and reviewed by the Mystum team. See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1590/1414-431x20143965, Alternate LINK

Title: Disentangling The Effects Of Insomnia And Night Work On Cardiovascular Diseases: A Study In Nursing Professionals

Subject: Cell Biology

Journal: Brazilian Journal of Medical and Biological Research

Publisher: FapUNIFESP (SciELO)

Authors: A. Silva-Costa, R.H. Griep, L. Rotenberg

Published: 2015-02-01

Everything You Need To Know

1

What is the main finding regarding Insomnia and Cardiovascular Diseases (CVDs)?

The study found that insomnia, a sleep disorder characterized by difficulty falling or staying asleep, significantly increased the risk of Cardiovascular Diseases (CVDs). This was observed in both Day Workers and Night Workers. For example, Day Workers with Insomnia had a 2.79 times greater chance of reporting a CVD diagnosis. For Night Workers experiencing insomnia, the risk was even higher, with a 3.07 times greater chance of CVD. These findings suggest that Insomnia, not just Night Work, is a primary driver of increased CVD risk in the population studied. The implications are that the quality of sleep is paramount, regardless of work schedule.

2

What was the study's main objective in relation to Night Work, Insomnia, and Cardiovascular Diseases (CVDs)?

The study investigated the link between Insomnia, Night Shift work, and Cardiovascular Diseases (CVDs). It involved 1307 female nurses from three public hospitals. Researchers analyzed the association between Insomnia and self-reported physician diagnoses of CVD in both Day Workers and Night Workers. The goal was to understand whether CVD risk was more closely tied to Night Work or to the Sleep disturbances that often accompany it, like insomnia. This distinction is critical for developing targeted interventions to protect the health of nursing professionals.

3

Does Night Work or Insomnia pose a greater risk to cardiovascular health?

The research indicates that the health risks, specifically the risk of Cardiovascular Diseases (CVDs), are more closely tied to Insomnia than to Night Work itself. The study found a significant association between Insomnia and CVD in both Day Workers and Night Workers. This means that the adverse effects on cardiovascular health were similar for both groups when experiencing Insomnia. The key takeaway is that addressing Insomnia and improving sleep quality should be a priority, irrespective of the work schedule.

4

Does the timing of sleep matter in relation to the findings?

Yes, according to the study, it does matter when you sleep. The research considered all sleep episodes, including both nocturnal and diurnal (daytime) sleep, particularly important for Night Workers who often sleep during the day. The findings emphasize that the timing of sleep, especially for Night Workers, should be considered when addressing Sleep disturbances such as Insomnia.

5

What are some possible reasons for the connection between Insomnia and Cardiovascular Diseases (CVDs)?

Several factors can explain the link between Insomnia and Cardiovascular Diseases (CVDs). Sleep deprivation, a hallmark of Insomnia, can disrupt the body's natural rhythms, leading to increased blood pressure and heart rate. Other mechanisms include inflammation, glucose metabolism disorders, and increased sympathetic nervous system activity. The research also accounted for other factors, further strengthening the argument that Insomnia plays a direct role. The implications are that managing Insomnia is essential for overall health and reducing the risk of CVD, regardless of the work schedule.

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