Surreal illustration of a heart with an anomalous coronary artery.

Rare Heart Anomaly Mimics Heart Attack: A Diagnostic Journey

"Unveiling a hidden cause of myocardial infarction: A case of anomalous coronary origin and the critical role of advanced imaging."


Coronary artery anomalies, though infrequent (occurring in approximately 0.6% to 1.5% of coronary angiographies), can present significant diagnostic and clinical challenges. While many individuals with these anomalies remain asymptomatic, others may experience life-threatening conditions. Therefore, accurate identification and visualization of these anomalies are critical for effective patient management.

However, in some instances, standard coronary angiography (CAG) may not suffice to precisely pinpoint the origin and course of an anomalous vessel. This is where advanced imaging techniques come into play. This article delves into a fascinating case report that underscores the importance of a comprehensive diagnostic approach.

We explore the case of a 54-year-old man presenting with an acute inferior myocardial infarction. The investigation led to the unexpected discovery of a rare coronary anomaly—the left circumflex coronary artery (LCX) originating from the first diagonal branch. This case highlights the diagnostic complexities and the value of multi-detector computed tomography (MD-CT) in clarifying such anatomical variations.

Decoding the Anomaly: How a Misplaced Artery Mimicked a Heart Attack

Surreal illustration of a heart with an anomalous coronary artery.

A 54-year-old male with a history of hypertension and a 30 pack-year smoking habit was admitted to the hospital due to chest pain. His initial electrocardiogram (ECG) revealed ST-segment elevation in leads II, III, and aVF, indicative of an acute inferior myocardial infarction.

Coronary angiography (CAG) was immediately performed. Surprisingly, the right coronary artery (RCA) showed no significant blockages. However, the left circumflex artery (LCX) was not visualized through conventional methods, raising suspicion of a complete blockage at its origin.
The diagnostic team encountered several challenges:
  • Initial suspicion of LCX ostial occlusion: Attempts to pass a guidewire into the LCX were unsuccessful, suggesting a potential blockage at its origin.
  • Discovery of an unusual vessel: A small artery originating from the first diagonal branch (D1) was identified, exhibiting thrombolysis in myocardial infarction (TIMI) flow grade 1, indicating severely restricted blood flow.
  • Intervention and further investigation: Balloon angioplasty was performed on the anomalous vessel and the D1. Subsequent angiograms revealed that the course of this vessel resembled that of a typical LCX.
To definitively map the precise anatomical course of the coronary arteries, 64-slice multi-detector computed tomography (MD-CT) was performed. This advanced imaging technique confirmed the anomalous origin of the LCX, clearly showing it arising from the D1 and coursing along the left atrioventricular groove.

The Takeaway: Why Recognizing Rare Anomalies Matters

This case underscores the critical importance of considering coronary artery anomalies in patients presenting with acute myocardial infarction, especially when standard angiographic findings are inconclusive. Advanced imaging techniques like MD-CT play a vital role in clarifying complex anatomical variations, ensuring accurate diagnosis and appropriate management. Early detection and precise delineation of the proximal course of anomalous coronary arteries are crucial for optimal patient outcomes.

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