Navigating Meningiomas in NF2: Surgery vs. Radiosurgery – Which Path is Right for You?
"Explore the latest research on managing multiple meningiomas associated with Neurofibromatosis Type 2 (NF2) and discover which treatment option—surgery or stereotactic radiosurgery—offers the best outcomes."
Neurofibromatosis type 2 (NF2) is a genetic condition characterized by the development of multiple tumors, most notably bilateral vestibular schwannomas and meningiomas. Meningiomas, tumors that arise from the meninges surrounding the brain and spinal cord, can pose significant challenges in NF2 patients due to their multiplicity and potential for neurological complications.
Traditionally, surgery has been the primary treatment for meningiomas. However, in NF2 patients with numerous tumors, complete surgical removal of all lesions may be impractical or impossible. This has led to the exploration of alternative treatment strategies, such as stereotactic radiosurgery (SRS). SRS is a non-invasive technique that delivers highly focused radiation to tumors, aiming to control their growth or shrink them. It represents a middle ground between doing nothing and risky surgery.
A recent study published in Neurosurgical Review delves into the debate between surgery and SRS for managing multiple meningiomas in NF2. By reviewing existing literature and presenting an illustrative case, the study sheds light on the effectiveness and safety of each approach. This article summarizes the key findings of this research, offering valuable insights for patients and healthcare professionals navigating the complexities of NF2-associated meningiomas.
The Surgery vs. Stereotactic Radiosurgery (SRS) Showdown

The study authors conducted a comprehensive search of medical databases to identify studies comparing surgery and SRS outcomes in NF2 patients with multiple meningiomas. The analysis included a total of 50 patients, with 27 undergoing SRS and 23 undergoing surgery. Here's a breakdown of what they discovered:
- Local tumor control was achieved in 81.5% of patients.
- Distal tumor control (preventing new tumors from forming) was achieved in 51.8% of patients.
- Complications were reported in 33% of patients.
- The average follow-up duration was 90 months, with no malignant transformations observed.
Making Informed Decisions About Your Health
The management of multiple meningiomas in NF2 patients requires careful consideration of the available treatment options. Both surgery and SRS have their own advantages and disadvantages. While surgery offers the potential for complete tumor removal, it may not always be feasible or safe in patients with numerous lesions. SRS, on the other hand, is a non-invasive approach that can effectively control tumor growth, but it may also carry a risk of complications.