Elderly patient receiving pharmacist care in a hospital setting

Is Your Hospital Stay Making You Healthier? How Pharmacists are Key to Elderly Care

"Uncover how hospital pharmacists are revolutionizing elderly inpatient care, reducing medication risks, and improving health outcomes."


As global fertility rates decline and life expectancy increases, the world's elderly population is rapidly growing. This demographic shift brings advancements in medical and pharmaceutical technologies, leading to greater use of healthcare services and medications for chronic and degenerative diseases. By 2025, Brazil is projected to have the sixth-largest elderly population globally, highlighting the urgent need for optimized healthcare strategies.

However, the natural physiological changes that come with aging can significantly impact how medications are processed by the body. This can result in exaggerated or inappropriate responses to medication, or even a complete lack of therapeutic benefit. This has raised widespread concern about the appropriate use of medication in older patients, making it a critical area of focus for healthcare professionals.

One of the key strategies for improving medication use in the elderly is to focus on reducing adverse drug events (ADEs), which can range from unnecessary drug use and inappropriate drug choices to a lack of long-term therapy reassessment. To tackle this, many guides and resources have been developed to help clinicians choose the best therapeutic options. Among these, the Beers List is the most frequently used tool for identifying potentially inappropriate medications for older adults.

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An Aging World and the Meaning of Eldercare

The number of elderly people worldwide began to surge in the second half of the 20th century; before then, five percent or less of the population in developed countries was over 65. Eldercare addresses older adults' daily needs through services such as assisted living, adult daycare, long-term care, nursing homes, hospice care, and home care. The term "elderly" is not universally welcomed: one study reported that 57% of adults over 65 disliked being called elderly. These demographic and language considerations help explain why hospital and pharmacy care for older adults must be both comprehensive and respectful.

A Coordinated but Individualized Approach

Care for older hospital patients generally aims to coordinate medication management with broader clinical and daily-living needs. In practice, the appropriate approach may vary according to a person's health status, support network, and care setting. Standard procedures can provide useful structure, but they may not address every patient's preferences or circumstances. Pharmacists therefore have an important opportunity to identify medication-related concerns while working alongside the wider care team.

The Evolving Role of Elderly Care

Elderly care has developed into a broad field rather than a single form of service. Its modern framework may include institutional, community, hospice, and home-based support. The role of pharmacists in this history is best understood as part of a wider movement toward coordinated care for older adults. Specific milestones vary by health system, so broad historical claims should be made cautiously.

The Pharmacist's Role: Reducing Medication Risks in Hospitals

Elderly patient receiving pharmacist care in a hospital setting

Adverse drug events are a significant concern in healthcare, particularly among hospitalized patients. According to research, 1% of all hospital admissions are caused by drug-drug interactions (DDIs), accounting for 16% of all hospital admissions due to adverse drug reactions (ADRs). In the United States, these ADRs lead to increased hospital costs, estimated at around $4,700 per admission, totaling $2 billion annually.

Given these alarming statistics, a study was conducted to assess the impact of hospital admission on improving pharmacotherapy among elderly inpatients. The study focused on potential drug interactions (pDDI), major pDDIs, and the use of potentially inappropriate medications (PIMs) at hospital admission, during hospitalization, and at discharge. The goal was to determine whether hospital admission provides an opportunity to enhance pharmacotherapy for elderly patients in a university hospital with a clinical pharmacist.

  • Study Design: A prospective cohort study was conducted, utilizing medical records of patients admitted to an internal medicine ward.
  • Data Collection: All admissions and prescriptions were monitored from March to August 2006.
  • Identification of Risks: Micromedex® DrugReax® and Beers Criteria 2015 were used to identify pDDI, major pDDI, and PIMs.
  • Analysis: Admission and discharge prescriptions were compared to assess changes in medication profiles.
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Evidence-Informed Medication Care

Recent discussion of elderly hospital care commonly emphasizes the need to review medications in the context of the whole patient. Pharmacists can contribute by examining treatment regimens, clarifying potential problems, and supporting communication across transitions of care. The strength of available evidence may differ across interventions and settings. Accordingly, medication services should be evaluated alongside patient goals, clinical outcomes, and continuity of care.

Limits of Hospital-Based Support

Pharmacist involvement does not eliminate every risk associated with hospitalization or complex medication use. Discharge misunderstandings, fragmented communication, changing prescriptions, and limited follow-up can still undermine otherwise careful plans. Benefits may also depend on staffing, coordination, and whether patients and caregivers can participate in decisions. A balanced assessment should therefore recognize both the value of pharmacy expertise and the system conditions that can limit its effect.

Comparing Care Settings

Medication needs can look different in hospitals, residential facilities, outpatient services, and the home. Hospital care may offer concentrated clinical expertise, while longer-term settings may provide more sustained observation of daily medication use. No single setting is automatically best for every older adult. Comparisons should account for safety, continuity, patient preferences, caregiver support, and access to qualified professionals.

The study revealed several significant changes between admission and discharge prescriptions. There was an increase in the proportion of patients using antithrombotic agents (76 vs. 144) and lipid-modifying agents (58 vs. 81). Additionally, there was a rise in the use of drugs for acid-related disorders (99 vs. 152), particularly omeprazole (61 vs. 87). Conversely, there was a decrease in the number of patients prescribed psycholeptics (73 vs. 32) and diazepam (54 vs. 13). Furthermore, the study observed a reduction in the proportion of patients exposed to polypharmacy (16.1% vs. 10.1%), at least one pDDI (44.5% vs. 32.8%), major pDDI (19.9% vs. 12.2%), or PIM (85.8% vs. 51.9%).

The Impact of Clinical Pharmacists on Patient Safety

The study concludes that admission to a hospital ward with a clinical pharmacist is associated with a significant reduction in the number of elderly inpatients exposed to polypharmacy, pDDIs, major pDDIs, and PIMs. This highlights the crucial role of clinical pharmacists in improving medication safety and ensuring better health outcomes for elderly patients. The presence of a clinical pharmacist provides an invaluable opportunity to optimize medication regimens, reduce potential risks, and enhance the overall quality of care for older adults during their hospital stay.

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Pharmacists as Care Coordinators

The central lesson is that pharmacists are most valuable when medication decisions are connected to the older person's broader care plan. Their contribution can include identifying risks, explaining treatment changes, and helping teams maintain consistency during transitions. This role complements rather than replaces physicians, nurses, caregivers, and patients. Effective elderly care therefore depends on collaboration and attention to the individual's goals.

Building More Continuous Care

Future progress will likely depend on linking hospital pharmacy services more closely with outpatient, residential, and home care. Better information sharing could help teams identify medication changes and unresolved concerns earlier. New approaches should be assessed not only for efficiency but also for safety, accessibility, and patient understanding. Research will need to clarify which models work best for different older populations and care environments.

Care Within an Aging System

The growth of the older population places pressure on health and social-care systems to support complex needs across multiple settings. Eldercare extends beyond hospitals to assisted living, adult daycare, long-term care, nursing homes, hospice, and home care. Systemic challenges can include workforce capacity, fragmented services, and unequal access to expertise. Addressing them requires coordination between clinical care, daily support, families, and community resources.

Respectful, Person-Centered Care

Medication safety is also a human issue involving trust, communication, independence, and dignity. Older adults may have preferences about how they are described and how their care is organized; one study reported that 57% of adults over 65 disliked being called elderly. Pharmacists can make care more understandable by listening carefully and explaining treatment in practical terms. The goal is not simply to manage prescriptions, but to help people participate meaningfully in decisions about their health.

What an admission-to-discharge cohort can show

Observational study (level 4 of 8)

This prospective cohort compared prescriptions at admission and discharge, so it can describe medication changes over the hospital stay but cannot establish that pharmacist involvement caused them.[1]

The findings concern elderly patients in an internal medicine ward at a university hospital with a clinical pharmacist; they do not by themselves show what would happen in other settings.[1]

The 2006 internal-medicine cohort and its prescription comparison

Study designObservational study[1]
PopulationElderly patients admitted to an internal medicine ward[1]
SettingInternal medicine ward at a University hospital that has a clinical pharmacist[1]
DurationBetween March and August 2006[1]
ComparisonAdmission and discharge prescriptions[1]
Main outcomeIncidence of potential drug interactions, major potential drug interactions, and use of potentially inappropriate medication[1]
p-valuep=0.025, p=0.002, p=0.010, and p<0.001[1]
Times cited4[1]

Questions the prescription comparison leaves open

  • Would the same pattern appear in other hospital wards or care settings beyond the studied internal medicine service?[1]

Medication terms used in the study

Potentially inappropriate medication (PIM)
Medication identified as potentially inappropriate using the Beers Criteria 2015.[1]

About this Article -

Written with AI assistance from published research, and reviewed by the Mystum team. See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1590/s1984-82502016000300005, Alternate LINK

Title: Does Hospital Admission Provide An Opportunity For Improving Pharmacotherapy Among Elderly Inpatients?

Subject: General Pharmacology, Toxicology and Pharmaceutics

Journal: Brazilian Journal of Pharmaceutical Sciences

Publisher: FapUNIFESP (SciELO)

Authors: Daniela Oliveira De Melo, Sílvia Storpirtis, Eliane Ribeiro

Published: 2016-09-01

Everything You Need To Know

1

What are adverse drug events (ADEs), and how does the Beers List help reduce medication risks for the elderly?

Adverse drug events (ADEs) are a big problem for older people, especially in hospitals. They include things like taking drugs that aren't needed, choosing the wrong drugs, or not checking if a medicine is still the right one to use over time. Guides like the Beers List help doctors and pharmacists pick safer medicines for older adults by pointing out drugs that might not be the best choice for them.

2

How did the study assess the impact of hospital admission on improving medication therapy among elderly inpatients, and what specific tools were used?

The study looked at elderly patients in a hospital. It tracked their medicines when they were admitted, while they were in the hospital, and when they were discharged. The goal was to see if being in the hospital, with a clinical pharmacist involved, could help improve how these patients used their medications. They specifically looked for potential drug interactions (pDDIs), major pDDIs, and potentially inappropriate medications (PIMs) using tools like Micromedex® DrugReax® and the Beers Criteria 2015.

3

What significant changes in medication profiles were observed between hospital admission and discharge in the study, and what do these changes suggest?

The study found several medication changes during hospitalization. More patients were prescribed antithrombotic and lipid-modifying agents. Also, there was an increase in medications for acid-related disorders, like omeprazole. On the other hand, fewer patients were prescribed psycholeptics and diazepam. Overall, the study showed that fewer patients were exposed to polypharmacy, potential drug interactions (pDDIs), major potential drug interactions, or potentially inappropriate medications (PIMs) when a clinical pharmacist was involved.

4

What role does a clinical pharmacist play in improving patient safety, and how does their involvement affect elderly inpatients' exposure to potentially harmful medications?

A clinical pharmacist plays a crucial role in improving patient safety, especially for the elderly. By carefully reviewing medications, they can reduce the risks associated with polypharmacy, potential drug interactions (pDDIs), major potential drug interactions, and potentially inappropriate medications (PIMs). This ensures that older patients receive the most appropriate and safe medication therapy, leading to better health outcomes during and after their hospital stay. This highlights their role in optimizing medication regimens and improving the overall quality of care for older adults.

5

The study shows an increase in certain medication prescriptions during hospitalization. What are the implications of these changes, and how should healthcare providers ensure patient safety in light of these adjustments?

The study mentioned that, from admission to discharge, there was a notable increase in the prescription of antithrombotic agents, lipid-modifying agents, and drugs for acid-related disorders like Omeprazole. This suggests a focus on managing conditions like cardiovascular issues and acid reflux more aggressively during the hospital stay. However, it's important to ensure that these changes are appropriate for each patient, considering their overall health and other medications they are taking, to avoid potential adverse drug events (ADEs).

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