Nurse preparing insulin injection with abstract medical background.

Insulin Injections: Are You Doing It Wrong?

"A new study reveals common insulin administration errors by nurses and what you can do to ensure proper technique."


For individuals managing diabetes, insulin injections are a cornerstone of treatment. Administering insulin might seem straightforward, but it requires precision and adherence to established medical guidelines. A recent observational study published in the journal Diabetes Spectrum sheds light on the current practices of insulin administration by nurses in a northern Greek hospital, revealing some surprising shortcomings.

The study highlights a gap between recommended practices and actual implementation, raising concerns about the potential for suboptimal diabetes management. These findings underscore the importance of staying informed and vigilant about proper injection techniques.

This article will delve into the key findings of the study, offering insights into common errors and practical tips for improving insulin injection techniques, whether you're a healthcare professional or an individual managing your diabetes.

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Why Technique Matters

Insulin therapy is crucial for people with Type 1 and advanced Type 2 diabetes. The effectiveness of diabetes therapy depends on correct insulin injection technique, yet improper use persists despite the convenience of insulin pens and established recommendations. Optimising injection technique includes improvements in delivery devices, teaching methods, monitoring, and complication management.

From Discovery to Personalised Care

Diabetes treatment has evolved through milestones spanning more than 3,500 years, from ancient Egyptian descriptions of “sweet urine” to modern continuous glucose monitoring and insulin pump therapy. The discovery and synthesis of insulin transformed treatment, while glucose testing helped patients share responsibility for managing therapy with physicians. A century after its discovery, insulin remains a cornerstone of diabetes treatment, alongside diet, physical activity, and newer technologies.

What the Research Says About Insulin Injection Practices

Nurse preparing insulin injection with abstract medical background.

The observational study, conducted in a Greek public hospital, assessed the insulin administration practices of 20 nurses across two medical wards. Researchers used non-participant observation and post-hoc interviews to gather data, comparing the observed techniques against international guidelines. A total of 100 insulin administrations were observed, followed by interviews with eight of the nurses.

The study revealed several areas where practice diverged from recommended guidelines:

  • Hand Hygiene: Only 61% of nurses washed their hands before administering insulin.
  • Glove Use: 70% of nurses wore gloves during injections. However, gloves were not always changed between patients.
  • Insulin Vial Preparation: A significant 64.5% of nurses did not clean the insulin bottle before inserting the needle.
  • Air Bubble Check: 42.7% of administrations did not include a check for air bubbles in the syringe.
  • Injection Site Assessment: In nearly 90% of cases, nurses failed to check the injection site for appropriateness or potential complications.
  • Skin Antisepsis: While 90.9% cleaned the skin with an alcohol swab, the necessity of this step has been questioned in recent literature.
  • Injection Angle: 70.9% of injections were administered vertically without creating a skinfold.
  • Post-Injection Care: A staggering 89.1% of instances were rated as having poor post-injection care, with insufficient time allowed before needle withdrawal.
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What Recent Studies Examine

Recent research continues to assess how insulin is taught and administered in clinical practice. A 2025 multicenter cross-sectional study of community nurses in a mountainous area of southwest Zhejiang, China, reported that institutional location, sex, knowledge of the latest guidelines, and insulin-injection training during the previous year were independent predictors of injection practice. Another cross-sectional survey in a northwest city of China examined patients’ injection techniques and the local complications associated with insulin injections. Research on nurses’ subcutaneous-injection preferences also questioned the evidential basis for routinely disinfecting skin before insulin injections.

When Individualisation Falls Short

An observational study of insulin administration by nurses in Northern Greece found that individualized patient assessment was practiced when selecting a 45° or 90° needle angle according to body structure. However, this adjustment was not accompanied by the recommended creation of a skinfold for injection. The finding shows that tailoring one part of technique does not necessarily mean that all recommended steps are being followed.

Pressure and Syringe Variables

A study of syringe-pump injection pressure compared different syringe volumes and speed settings. With 30 ml syringes, injection pressures fluctuated in most of the six syringe pumps when the speed was below 5 ml.h-1. This indicates that syringe volume and pump-speed settings can affect pressure stability in syringe-pump delivery.

These findings indicate a concerning level of non-compliance with established guidelines, potentially impacting the effectiveness and safety of insulin administration.

Practical Tips for Improved Insulin Injections

Whether you're a healthcare provider or managing your own diabetes, adopting best practices for insulin injection is crucial. Here's a concise guide:

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Refreshing Established Guidance

The Forum for Injection Technique and Therapy Expert Recommendations, known as FITTER, brings together physicians, nurses, diabetes educators, certified diabetes care and education specialists, and other allied healthcare professionals. FITTER Forward provides an evidence-based refresh of the 2016 injection-technique recommendations, drawing on a literature review and expert consensus. The updated recommendations address advances in insulin-delivery technology while retaining widely established key messages.

Innovation, Education, and Partnerships

The 2025 Injection Technique Matters guidance presents innovation, education, and strong community partnerships as routes to advancing insulin-delivery standards. The initiative is supported by embecta, which states that it is committed to improving injection technique and outcomes for people living with diabetes. This future-facing approach links technical progress with education and community collaboration.

Quality Improvement in Practice

A 2026 study examined insulin-injection practices at the primary community level using questionnaires and targeted data analysis. It implemented a special quality-management program for continuous improvement, with the aim of enhancing injection standardization and evaluating its effectiveness in a real-world community setting. A separate 2022 study assessed patients’ insulin-injection practices and examined their effect on glycemic control.

  • Student observers recorded practice, while interviews captured nurses' answers; these sources may describe practice differently, and the excerpts do not quantify any difference.[1]
  • Staff reported shortages and limited time to teach students, but the study does not establish how much these pressures contributed to the observed practices.[2]
  • The checklist drew on international literature and guidelines, which the authors note are not uniform.[1]
Study at a glance
PopulationNurses from two medical wards[1]
Sample size20 nurses assessed; 8 nurses interviewed[1]
SettingA Greek public hospital in Northern Greece[1]
ComparisonInsulin management and administration was compared to international guidelines[1]
Main outcomeNurses’ insulin administration practices and compliance with international guidelines[1]
Times cited22[1]

A 2023 paper characterized skin disinfection before insulin injections as a longstanding ritual despite limited evidence for its necessity, echoing the Greek study's uncertainty about that practice.[2] [3]

What remains unresolved about the observed practices

  • Did the reported preparation and checking lapses vary between the two wards or among nurses? The supplied results do not break them down by ward or individual.[1]
  • How often did practices recorded during observation differ from the answers nurses gave in interviews? The study used both sources, but the cited material gives no comparison.[1]

About this Article -

Written with AI assistance from published research, and reviewed by the Mystum team. See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.2337/ds16-0001, Alternate LINK

Title: In-Hospital Administration Of Insulin By Nurses In Northern Greece: An Observational Study

Subject: Endocrinology, Diabetes and Metabolism

Journal: Diabetes Spectrum

Publisher: American Diabetes Association

Authors: Dimitrios Theofanidis

Published: 2017-08-01

Everything You Need To Know

1

What were the main issues with insulin administration practices that were identified in the study?

The study revealed that a significant percentage of nurses did not adhere to recommended practices for insulin administration. Specifically, there were issues with hand hygiene (61% washed hands), glove use (70% used gloves, but not always changed between patients), insulin vial preparation (64.5% did not clean the vial), air bubble checks (42.7% didn't check), injection site assessment (90% failed to check), injection angle (70.9% injected vertically without a skinfold), and post-injection care (89.1% had poor post-injection care). Each of these deviations can impact the effectiveness and safety of insulin delivery.

2

Why are hand hygiene and proper glove usage so important when giving insulin injections, and what did the study reveal about these practices?

Proper hand hygiene, which involves washing hands before administering insulin, is crucial in preventing infections. The study showed only 61% of nurses followed this guideline. Furthermore, while 70% of nurses used gloves, they weren't always changed between patients, posing a risk of cross-contamination. The failure to clean the insulin vial before use (64.5% did not) introduces another potential source of contamination. These lapses in basic hygiene can compromise patient safety and increase the risk of localized or systemic infections.

3

Why is it necessary to check for air bubbles and assess the injection site before administering insulin?

Checking for air bubbles in the syringe, which 42.7% of administrations omitted, is important because injecting air can affect the accuracy of the insulin dose. Failing to assess the injection site, which occurred in nearly 90% of cases, can lead to complications such as lipohypertrophy (fatty lumps under the skin) or infections. Both of these errors can impact insulin absorption and glycemic control. Injection site rotation is a key element that reduces these risks.

4

How does the angle of injection and post-injection care affect insulin absorption and effectiveness?

Administering insulin at the correct angle, often involving a skinfold to ensure subcutaneous injection, is vital for proper absorption. The study found that 70.9% of injections were given vertically without creating a skinfold, potentially leading to intramuscular injections, which have a faster and less predictable absorption rate. Poor post-injection care, observed in 89.1% of instances, including insufficient time before needle withdrawal, can cause insulin leakage and impact the dose delivered. Appropriate technique ensures consistent and predictable insulin absorption.

5

Does the research discuss specific types of insulin or needle sizes and their effects on the injection process?

The study did not directly address specific types or brands of insulin, or the impact of different needle sizes. These factors can influence insulin absorption rates and injection comfort. Different types of insulin (rapid-acting, short-acting, intermediate-acting, long-acting) have different onset and duration of action, and the correct choice depends on individual needs and blood glucose patterns. Needle size also impacts injection depth and patient comfort, with shorter needles often recommended to reduce the risk of intramuscular injection.

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