Interplay of heritage and environment in asthma risk.

Asthma and Immigration: Unmasking the Generational Risk

"A deep dive into how asthma incidence shifts across immigrant generations in Canada, revealing surprising links to environmental factors and early life exposures."


Asthma, a chronic respiratory disease characterized by inflammation and narrowing of the airways, poses a significant public health challenge worldwide. In Canada, a country known for its high asthma prevalence and diverse immigrant population, understanding the interplay between immigration and asthma becomes crucial. Recent research sheds light on how asthma incidence varies across immigrant generations, revealing surprising patterns linked to environmental factors and early life exposures.

A new population-based cohort study, recently published, examined generational patterns of asthma incidence among immigrants in Canada over two decades. The study, which followed a large cohort of immigrants and their children, uncovered that while first-generation immigrants often experience lower asthma rates compared to long-term residents, their Canadian-born children face a significantly higher risk.

This article explores the key findings of this study, unraveling the complex relationship between immigration, environmental exposures, and asthma risk. By understanding these patterns, we can gain valuable insights into targeted prevention strategies and public health initiatives aimed at reducing the burden of asthma in Canada's diverse population.

AI Search Multiple angles on this topic

Current Asthma Burden

CDC data report that 8.7% of U.S. adults aged 18 and older and 6.2% of children younger than 18 currently had asthma in 2022. The CDC also reports 4.9 million annual office visits for asthma. Research on immigrant generational status indicates that migration can change exposure to pollutants, allergens, socioeconomic conditions, diet, and medical services, potentially affecting asthma risk.

Reviewing Migration and Asthma

Systematic reviews assess the relationship between immigration status and the development of asthma and allergic diseases using methods aligned with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, or PRISMA, statement. The evidence base has expanded as researchers examine potential causal pathways. However, findings have been contradictory, particularly regarding migration status and other social determinants of health.

Country of Origin as a Key Variable

Migration research has identified country of origin as a key variable when studying asthma and allergies. A systematic review noted that migration studies have also faced limitations in representing industrialized Western countries. These observations helped establish the importance of comparing populations by origin rather than treating immigrants as a single uniform group.

The Generational Asthma Paradox: Understanding the Shifting Risks

Interplay of heritage and environment in asthma risk.

The study's findings highlight a fascinating paradox: first-generation immigrants, upon arrival in Canada, tend to have lower rates of asthma compared to the long-term Canadian population. This observation aligns with the "healthy immigrant effect," a phenomenon where newly arrived immigrants often exhibit better health outcomes than the native-born population. This advantage could be attributed to various factors, including self-selection of healthier individuals for migration, different lifestyle habits, or varying exposures in their countries of origin.

However, the study revealed a concerning trend: the children of immigrants born in Canada displayed a significantly higher incidence of asthma compared to both their parents and the children of long-term residents. This suggests that factors within the Canadian environment play a crucial role in shaping asthma risk for subsequent generations.

  • Lower Initial Risk: Immigrants often arrive with a lower asthma incidence.
  • Rising Risk in Children: Canadian-born children of immigrants see a higher asthma incidence.
  • Environmental Influence: Canadian environment and lifestyle are key contributing factors.
AI Search Multiple angles on this topic

Current Research Directions

A 2019 review on asthma emphasized that remaining knowledge gaps require technological advances and human knowledge from diverse disciplines, with patients at the center. A systematic review and meta-analysis of children migrating with their parents included a 2019 Canada cohort of 422,305 participants and 968,256 records, using the ICES database to examine physical health outcomes including asthma. Another study reported asthma prevalence of 32% among first-generation immigrants and 34% among second-generation immigrants, compared with 46% among non-immigrants.

Limits of Administrative Data

A population-based cohort study of South Asian immigrants to Canada and their children identified limitations in using administrative data. One limitation was grouping patients according to World Bank economic classifications. Those regional categories included populations that were ethnically and genetically diverse, which can make it difficult to interpret group-level asthma findings as reflecting a single shared risk.

The increased asthma risk among Canadian-born children of immigrants points towards the influence of environmental exposures encountered early in life, even in utero. These exposures can include a range of factors, from air pollution and allergens to dietary changes and altered microbial environments. The timing of exposure appears critical, suggesting that the developing immune system of infants and young children may be particularly vulnerable to these environmental triggers.

Implications for Prevention and Public Health

The findings from this study offer valuable insights for asthma prevention and public health strategies in Canada. By understanding the generational shift in asthma risk, interventions can be targeted to address the specific vulnerabilities of Canadian-born children of immigrants. Future research should focus on identifying the precise environmental factors driving this increased risk, allowing for the development of tailored interventions to mitigate these exposures and promote respiratory health for all children in Canada.

AI Search Multiple angles on this topic

Environmental Prevention Frontiers

One study cited in the source material estimates that asthma incidence will continue to rise alongside increasing air pollution severity. A 2026 review describes air pollution and occupational asthma triggers as modifiable environmental and occupational exposures that influence asthma development and exacerbation. Another 2026 analysis proposes fine-scale asthma-risk estimates to guide early community-based screening, public-health messaging, and targeted infrastructure improvements.

Evidence Across Migration Studies

A systematic review examined asthma and allergic diseases in relation to international immigration using methods consistent with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, or PRISMA. This approach reflects the need to synthesize evidence across studies rather than rely on a single population or outcome. The source material presents the review as part of a broader effort to understand how migration relates to respiratory and allergic health.

Acculturation and Childhood Asthma

Research on Latino children has examined how immigration and acculturation-related factors affect asthma morbidity outcomes. The reviewed studies also considered family cohesion alongside these processes. The authors summarize existing assessment procedures and findings while identifying directions for future research on how immigration-related experiences shape pediatric asthma.

What Ontario's records can-and cannot-show

Observational study (level 4 of 8)

This retrospective population-based cohort tracked asthma incidence in Ontario residents using provincial administrative data. Its scale supports a comparison across groups, but the observational design cannot establish that immigration or birthplace caused the differences.[1]

The analysis covered residents with and without an asthma diagnosis over fiscal years 1996–2012; it measured incidence rather than identifying the exposures that produced it.[1]

The generational contrast points to early exposure

The contrast between immigrant residents and their Ontario-born children is consistent with a role for conditions encountered around pregnancy or early life, but the cohort did not isolate a particular exposure or prove a causal pathway.[1]

The authors noted that the higher incidence among children, but not their parents, made being born in Canada relevant to the observed pattern; birthplace itself does not identify why the pattern occurred.[1]

Ontario asthma incidence in a retrospective cohort

Study designObservational study[1]
Sample sizeApproximately 11.7 million records[1]
SettingOntario, Canada[1]
DurationFiscal years 1996–2012[1]
ComparisonImmigrants compared with long-term residents[1]
Main outcomeAsthma incidence[1]
Effect sizeAsthma incidence was lower among immigrants (IRR = 0.30); Ontario-born children of immigrants from most world regions had higher incidence (IRR = 1.44)[1]
Confidence interval0.30–0.30 for immigrants; 1.43–1.45 for Ontario-born children of immigrants[1]
p-valueP < 0.001[1]
Times cited9[1]

How the Ontario cohort relates to other migration research

A separate systematic review reported a pooled prevalence odds ratio for asthma in immigrants versus host populations. That prevalence comparison is not directly interchangeable with this Ontario cohort’s incidence rate ratios.[1] [2]

What the incidence pattern leaves unresolved

  • Which in utero or early-life exposures, if any, account for the higher incidence among Ontario-born children of immigrants?[1]
  • Why did overall Ontario asthma incidence decline during the study period, and how did that broader trend relate to the group comparisons?[1]

Terms used in the cohort

Incidence rate ratio
A comparison of asthma incidence between groups.[1]
Long-term residents
Ontario residents classified separately from immigrants in the study.[1]
Retrospective cohort study
A population-based study using existing records to examine residents over a defined period.[1]

About this Article -

Written with AI assistance from published research, and reviewed by the Mystum team. See our About page for more information.

This article is based on research published under:

DOI-LINK: 10.1513/annalsats.201803-187oc, Alternate LINK

Title: Generational Patterns Of Asthma Incidence Among Immigrants To Canada Over Two Decades. A Population-Based Cohort Study

Subject: Pulmonary and Respiratory Medicine

Journal: Annals of the American Thoracic Society

Publisher: American Thoracic Society

Authors: Dhenuka Radhakrishnan, Astrid Guttmann, Teresa To, John Joseph Reisman, Braden D. Knight, Nassim Mojaverian, Douglas G. Manuel, Jennifer L. Gommerman, Kenneth Croitoru, Eric I. Benchimol

Published: 2019-02-01

Everything You Need To Know

1

What exactly is asthma, and why should we be concerned about it in the context of immigration?

Asthma is a chronic respiratory disease characterized by inflammation and narrowing of the airways. This is significant because it poses a substantial public health challenge, especially in countries like Canada with a diverse immigrant population and high asthma prevalence. Understanding how asthma incidence varies across immigrant generations can lead to better targeted prevention and public health strategies.

2

What is the 'healthy immigrant effect,' and how does it relate to asthma rates among new immigrants?

The 'healthy immigrant effect' is a phenomenon where newly arrived immigrants often exhibit better health outcomes, including lower asthma rates, compared to the native-born population. This could be due to healthier individuals self-selecting for migration, different lifestyle habits, or varying exposures in their countries of origin. However, this effect tends to diminish in subsequent generations, indicating the influence of the new environment.

3

Why do children of immigrants born in Canada have a higher risk of developing asthma?

Canadian-born children of immigrants display a significantly higher incidence of asthma compared to both their parents and children of long-term residents. This suggests that environmental factors within Canada play a crucial role in shaping asthma risk for subsequent generations. This highlights the need to examine and address specific environmental exposures impacting this group.

4

What specific environmental factors might be contributing to the increased asthma risk in Canadian-born children of immigrants?

Environmental exposures encountered early in life, potentially even in utero, are likely key factors contributing to the increased asthma risk among Canadian-born children of immigrants. These exposures can include things like air pollution, allergens, dietary changes, and altered microbial environments. The timing is critical because the developing immune system of infants and young children is particularly vulnerable to these environmental triggers.

5

How can we use the findings about asthma and immigrant generations to improve public health?

Understanding the generational shift in asthma risk allows interventions to be targeted to address the specific vulnerabilities of Canadian-born children of immigrants. Future research should pinpoint the precise environmental factors driving this increased risk. This knowledge will enable the development of tailored interventions to mitigate these exposures and promote respiratory health for all children.

Newsletter Subscribe

Subscribe to get the latest articles and insights directly in your inbox.